PT  - JOURNAL ARTICLE
AU  - Williamson, E M
AU  - Miller, J F
AU  - Seabright, M
TI  - Pericentric inversion (13) with two different recombinants in the same family.
AID  - 10.1136/jmg.17.4.309
DP  - 1980 Aug 01
TA  - Journal of Medical Genetics
PG  - 309--312
VI  - 17
IP  - 4
4099  - http://jmg.bmj.com/content/17/4/309.short
4100  - http://jmg.bmj.com/content/17/4/309.full
SO  - J Med Genet1980 Aug 01; 17
AB  - A family is described in which a pericentric inversion (13) was discovered in the father after the birth of an abnormal baby. In a further pregnancy amniocentesis was carried out. The fetal karyotype showed a rec(13)dup p,inv(13)(p11q22). The fetus's abnormalities were similar to those observed in the first child. Family studies showed that a first cousin, mentally retarded, had a rec(13)dup q,inv(13)(p11q22) karyotype. In this family, the risk of occurrence of a recombinant in offspring of an inversion carrier could be as high as 40%.