PT  - JOURNAL ARTICLE
AU  - Tsui, Y C
AU  - Creasy, M R
AU  - Hultén, M A
TI  - The effect of the male contraceptive agent Gossypol on human lymphocytes in vitro: traditional chromosome breakage, micronuclei, sister chromatid exchange, and cell kinetics.
AID  - 10.1136/jmg.20.2.81
DP  - 1983 Apr 01
TA  - Journal of Medical Genetics
PG  - 81--85
VI  - 20
IP  - 2
4099  - http://jmg.bmj.com/content/20/2/81.short
4100  - http://jmg.bmj.com/content/20/2/81.full
SO  - J Med Genet1983 Apr 01; 20
AB  - The male antifertility agent Gossypol did not affect the level of traditional chromosome breakage or number of micronuclei in 66-hour lymphocyte cultures at concentrations up to 40 micrograms/ml. It did increase the frequency of SCE slightly, although the inter-individual variation was greater than the increase resulting from Gossypol, and, even at the highest concentration (40 micrograms/ml), the SCE rate was still within the normal range. It also affected cell kinetics, reducing the mitotic index and the proportion of second and third metaphases after BUdR incorporation.