TY - JOUR T1 - Negro alpha-thalassaemia: genetic studies in homozygous sickle cell disease. JF - Journal of Medical Genetics JO - J Med Genet SP - 281 LP - 284 DO - 10.1136/jmg.17.4.281 VL - 17 IS - 4 AU - G R Serjeant AU - K P Mason AU - B E Serjeant Y1 - 1980/08/01 UR - http://jmg.bmj.com/content/17/4/281.abstract N2 - Interaction with the alpha-thalassaemia phenotypes lowers the proportion of Hb S in the sickle cell trait and influences the mean cell volume and proportional Hb A2 in homozygous sickle cell (SS) disease. By assigning somewhat arbitrary values to the alpha-thalassaemia 1 and alpha-thalassaemia 2 phenotypes in these conditions, it has been possible to investigate the patterns of inheritance of alpha-thalassaemia in black populations. The results strongly support the hypothesis that the alpha-thalassaemia 1 phenotype represents homozygosity for alpha-thalassaemia 2. ER -