RT Journal Article
SR Electronic
T1 Problem of sex ratio in cases of type I syndactyly.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 108
OP 113
DO 10.1136/jmg.14.2.108
VO 14
IS 2
A1 C M Woolf
A1 D L Cone
YR 1977
UL http://jmg.bmj.com/content/14/2/108.abstract
AB Fifty pedigrees of type I syndactyly were analysed for sex ratio and segreation pattern. Thirty-four of the pedigrees were from the published reports; 16 were collected in the State of Utah. Pedigrees with affected individuals showing webbing between the second and third toes are characterized by a sex ratio of affected individuals favouring males and a highly significant excess of affected sons of heterozygous fathers. A similar distorted segregation pattern is present in those pedigrees when the webbing involves the second and third toes and/or the third and fourth fingers, but not in those pedigrees when the webbing involves other digits. The reason for the distorted segregation pattern is unknown. Hypothesis include abnormal chromosome segregation and gametic selection.