RT Journal Article
SR Electronic
T1 Dissociation as probable origin of mosaic 45,XY,t(15;21)/46,XY,i(21q).
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 305
OP 310
DO 10.1136/jmg.15.4.305
VO 15
IS 4
A1 Vianna-Morgante, A M
A1 Nunesmaia, H G
YR 1978
UL http://jmg.bmj.com/content/15/4/305.abstract
AB A patient is described with some features of Down's syndrome and a 45,XY, t(15;21)(15qter leads to 15p13::21p11 leads to 21qter)/46,XY,i(21)(qter leads to cen leads to qter) karyotype. Two mechanisms are proposed for the origin of the mosaicism, one assuming the dissociation of a translocation (15;21) chromosome already present in the zygote, and the other involving a chromatid translocation in a 46,XY zygote. The possible independent origin of the two cell lines is also considered.