PT  - JOURNAL ARTICLE
AU  - Vianna-Morgante, A M
AU  - Nunesmaia, H G
TI  - Dissociation as probable origin of mosaic 45,XY,t(15;21)/46,XY,i(21q).
AID  - 10.1136/jmg.15.4.305
DP  - 1978 Aug 01
TA  - Journal of Medical Genetics
PG  - 305--310
VI  - 15
IP  - 4
4099  - http://jmg.bmj.com/content/15/4/305.short
4100  - http://jmg.bmj.com/content/15/4/305.full
SO  - J Med Genet1978 Aug 01; 15
AB  - A patient is described with some features of Down's syndrome and a 45,XY, t(15;21)(15qter leads to 15p13::21p11 leads to 21qter)/46,XY,i(21)(qter leads to cen leads to qter) karyotype. Two mechanisms are proposed for the origin of the mosaicism, one assuming the dissociation of a translocation (15;21) chromosome already present in the zygote, and the other involving a chromatid translocation in a 46,XY zygote. The possible independent origin of the two cell lines is also considered.