RT Journal Article
SR Electronic
T1 Predisposition to spina bifida: Search for a relation to maternal gastric acid secretion.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 332
OP 334
DO 10.1136/jmg.14.5.332
VO 14
IS 5
A1 Stanway, P A
A1 Samloff, I M
A1 Brace, C J
A1 Renwick, J H
YR 1977
UL http://jmg.bmj.com/content/14/5/332.abstract
AB The peak acid output of the stomach in a group of 71 mothers of spina bifida children and in 71 matched controls was estimated indirectly by the serum level of group I pepsinogens. The mean levels did not differ significantly, suggesting that the conjectured teratogen is not specially acid-labile. The variance was significantly higher in index subjects than in controls, but the interpretation of this finding is not clear.