PT - JOURNAL ARTICLE AU - T J David AU - A B Ajdukiewicz TI - A family study of coeliac disease. AID - 10.1136/jmg.12.1.79 DP - 1975 Mar 01 TA - Journal of Medical Genetics PG - 79--82 VI - 12 IP - 1 4099 - http://jmg.bmj.com/content/12/1/79.short 4100 - http://jmg.bmj.com/content/12/1/79.full SO - J Med Genet1975 Mar 01; 12 AB - Thirteen of 141 cases (9 percent) of overt, biopsy proven coeliac disease had a definitely affected relative. The pattern of inheritance in these families is compatible with an incompletely penetrant autosomal dominant gene. There was a female preponderance in the adults and the sporadic cases, but not in the children or the familial cases. The series included a pair of concordant and probably monozygotic twins. The authors believe that coeliac disease, as defined at present, is a heterogeneous condition.