TY - JOUR T1 - Thalassaemia in northern Liberia. A survey in the Mount Nimba area. JF - Journal of Medical Genetics JO - J Med Genet SP - 55 LP - 63 DO - 10.1136/jmg.12.1.55 VL - 12 IS - 1 AU - M C Willcox Y1 - 1975/03/01 UR - http://jmg.bmj.com/content/12/1/55.abstract N2 - A population survey in northern Liberia showed an average incidence of 9 percent of beta-thalassaemia trait. There was considerable tribal variation, the highest rates being mainly found in tribes having a low incidence of Hb S. A single example of deltabeta-thalassaemia trait was also found; the incidence of delta-chain variants was 1.8 percent. The effect of malaria on Hb A2 levels was investigated but appeared to be negligible. The problems of beta-thalassaemia and Hb S occurring in the same population are discussed. It is considered that, although made on a local sample, the results of this survey indicate a high incidence of beta-thalassaemia trait elsewhere in Liberia and that this is a suitable are for investigations of linkage at beta- and delta-chain loci. No conclusion is at present possible from the data on the presence of alpha-thalassaemia although 10 percent of neonates were found to have increased levels of Hb Barts. ER -