RT Journal Article
SR Electronic
T1 New allele at cholinesterase locus 1.
JF Journal of Medical Genetics
JO J Med Genet
FD BMJ Publishing Group Ltd
SP 38
OP 42
DO 10.1136/jmg.13.1.38
VO 13
IS 1
A1 P J Garry
A1 A A Dietz
A1 T Lubrano
A1 P C Ford
A1 K James
A1 H M Rubinstein
YR 1976
UL http://jmg.bmj.com/content/13/1/38.abstract
AB A family (H-J pedigree) segregating for the A and F alleles at cholinesterase locus 1 is described. Apparent anomalous results led to the recognition of a new allele (E1j) also segregating in the family. The data are consistent with the hypothesis that the the E1j causes reduction of 'usual' (E1u) molecules by about 66%. Whether this is because of retarded synthesis or accelerated degradation of serum cholinesterase remains to be determined.