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Although I lack expertise in screening methods designed to detect the
presence of mutations that predispose to disease, the findings reported on
BRCA1 by Eng et al. are clearly important. It is essential that a
systematic blinded comparison of methods should be carried out to
establish or confirm the validity of genetic screening tests. This is of
particular importance in cases where the predisposing ris...
Although I lack expertise in screening methods designed to detect the
presence of mutations that predispose to disease, the findings reported on
BRCA1 by Eng et al. are clearly important. It is essential that a
systematic blinded comparison of methods should be carried out to
establish or confirm the validity of genetic screening tests. This is of
particular importance in cases where the predisposing risk of cancer
associated with the mutations is high and the individuals tested must make
important decisions based on the outcome of such tests. Hence, the
scientific and medical communities are obliged to assure the accuracy and
reliablity of tests offered to identify mutations that carry profound
consequences for the individual patient.
Dear Editor
Although I lack expertise in screening methods designed to detect the presence of mutations that predispose to disease, the findings reported on BRCA1 by Eng et al. are clearly important. It is essential that a systematic blinded comparison of methods should be carried out to establish or confirm the validity of genetic screening tests. This is of particular importance in cases where the predisposing ris...
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