Re: Beckwith-Wiedemann syndrome and assisted reproduction technology (ART)
Regarding the article by Maher et al, it should be noted that the correct method for calculating the required probability would be to use the binomial distribution. (Of course the Poisson approximation is quite accurate here). However because of the highly skewed nature of the null distribution the appropriate probability for a two sided test is 0.004 ie the one sided probability should not be doubled. Of course, this does not affect the conclusions drawn.
(1) ER Maher, LA Brueton, SC Bowdin, A Luharia, W Cooper, TR Cole, F Macdonald, JR Sampson, CL Barratt, W Reik, and MM Hawkins. Beckwith-Wiedemann syndrome and assisted reproduction technology (ART). J Med Genet 2003;40:62-64.