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Mutations of the β myosin heavy chain gene in hypertrophic cardiomyopathy: critical functional sites determine prognosis
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Objectives: To assess patients with different types of mutations of the β myosin heavy chain (β MHC) gene causing hypertrophic cardiomyopathy (HCM) and to determine the prognosis of patients according to the affected functional domain of β MHC.
Design and setting: Cohort study of subjects referred to an HCM clinic at an academic hospital.
Patients: 70 probands from the HCM clinic were screened for …