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Research Article
Absence of linkage between chromosome 21 loci and familial amyotrophic lateral sclerosis.
  1. A King,
  2. H Houlden,
  3. J Hardy,
  4. R Lane,
  5. A Chancellor,
  6. J de Belleroche
  1. Department of Biochemistry, Charing Cross and Westminister Medical School, London.

    Abstract

    Familial amyotrophic lateral sclerosis (FALS) has recently been shown to be linked to chromosome 21 markers in a subset of families. However, we were unable to show linkage between FALS and chromosome 21 markers which flank the putative FALS locus in UK families.

    https://doi.org/10.1136/jmg.30.4.318

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