Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Chiara Corradi; Giulia Lencioni; Manuel Gentiluomo; Alessio Felici; Anna Latiano; Gediminas Kiudelis; Casper H J van Eijck; Katalin Marta; Rita T Lawlor; Francesca Tavano; Ugo Boggi; Frederike Dijk; Giulia Martina Cavestro; Roel C H Vermeulen; Thilo Hackert; Maria Chiara Petrone; Faik Güntac Uzunoğlu; Livia Archibugi; Jakob R Izbicki; Luca Morelli; Alessandro Zerbi; Stefano Landi; Hannah Stocker; Renata Talar-Wojnarowska; Gregorio Di Franco; Péter Hegyi; Cosimo Sperti; Silvia Carrara; Gabriele Capurso; Maria Gazouli; Hermann Brenner; Stefania Bunduc; Olivier Busch; Francesco Perri; Martin Oliverius; Péter Jeno Hegyi; Mara Goetz; Pasquale Scognamiglio; Andrea Mambrini; Paolo Giorgio Arcidiacono; Edita Kreivenaite; Juozas Kupcinskas; Tamas Hussein; Stefano Ermini; Anna Caterina Milanetto; Pavel Vodicka; Vytautas Kiudelis; Viktor Hlaváč; Pavel Soucek; George E Theodoropoulos; Daniela Basso; John P Neoptolemos; Mateus Nóbrega Aoki; Raffaele Pezzilli; Claudio Pasquali; Roger Chammas; Sabrina Gloria Giulia Testoni; Beatrice Mohelnikova-Duchonova; Maurizio Lucchesi; Cosmeri Rizzato; Federico Canzian; Daniele Campa

doi:10.1136/jmg-2022-108910

Article info

Cancer genetics

Original research

Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Authors

Chiara Corradi Department of Biology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Giulia Lencioni Department of Biology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Manuel Gentiluomo Department of Biology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Alessio Felici Department of Biology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Anna Latiano Division of Gastroenterology and Research Laboratory, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articles Google scholar articles
Gediminas Kiudelis Department of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articles Google scholar articles
Casper H J van Eijck Department of Surgery, Erasmus Medical Center, Erasmus University, Rotterdam, Netherlands PubMed articles Google scholar articles
Katalin Marta Center for Traslational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Disease, Heart and Vascular Center, Semmelweis University, Budapest, Hungary PubMed articles Google scholar articles
Rita T Lawlor ARC-NET, Centre for Applied Research on Cancer, University and Hospital Trust of Verona, Verona, Italy PubMed articles Google scholar articles
Francesca Tavano Division of Gastroenterology and Research Laboratory, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articles Google scholar articles
Ugo Boggi Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy PubMed articles Google scholar articles
Frederike Dijk Department of Pathology, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands PubMed articles Google scholar articles
Giulia Martina Cavestro Division of Experimental Oncology, Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, IRCCS San Raffaele Scientific Institute, Milano, Italy PubMed articles Google scholar articles
Roel C H Vermeulen University of Utrect, Utrecht, Netherlands PubMed articles Google scholar articles
Thilo Hackert Department of General Surgery, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Maria Chiara Petrone Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Faik Güntac Uzunoğlu Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Livia Archibugi Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy Digestive and Liver Disease Unit, Sant’Andrea Hospital, Roma, Italy PubMed articles Google scholar articles
Jakob R Izbicki Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Luca Morelli General Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, Università di Pisa, Pisa, Italy PubMed articles Google scholar articles
Alessandro Zerbi Pancreatic Unit, IRCCS Humanitas Research Hospital, Rozzano, Italy Department of Biomedical Sciences, Humanitas University, Milan, Italy PubMed articles Google scholar articles
Stefano Landi Department of Biology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Hannah Stocker Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany Network Aging Research (NAR), Heidelberg University, Heidelberg, Germany PubMed articles Google scholar articles
Renata Talar-Wojnarowska Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland PubMed articles Google scholar articles
Gregorio Di Franco General Surgery, Department of Translational Research and New Technologies in Medicine and Surgery, Università di Pisa, Pisa, Italy PubMed articles Google scholar articles
Péter Hegyi Center for Traslational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Disease, Heart and Vascular Center, Semmelweis University, Budapest, Hungary Institute for Translational Medicine, Medical School, University of Pécs, Pecs, Hungary Janos Szentagothai Research Center, University of Pecs, Pecs, Hungary PubMed articles Google scholar articles
Cosimo Sperti Department of Surgery-DiSCOG, Padua University Hospital, Padova, Italy PubMed articles Google scholar articles
Silvia Carrara Endoscopic Unit, Department of Gastroenterology, IRCCS Humanitas Research Hospital, Rozzano, Italy PubMed articles Google scholar articles
Gabriele Capurso Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy Digestive and Liver Disease Unit, Sant’Andrea Hospital, Roma, Italy PubMed articles Google scholar articles
Maria Gazouli Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece PubMed articles Google scholar articles
Hermann Brenner Division of Clinical Epidemiology and Aging Research, Cancer Research Center (DKFZ), Heidelberg, Germany German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Stefania Bunduc Center for Traslational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Disease, Heart and Vascular Center, Semmelweis University, Budapest, Hungary Carol Davila University of Medicine and Pharmacy, Bucarest, Romania PubMed articles Google scholar articles
Olivier Busch Department of Surgery, Amsterdam UMC, University of Amsterdam, Cancer Center Amsterdam, Amsterdam, Netherlands PubMed articles Google scholar articles
Francesco Perri Division of Gastroenterology and Research Laboratory, IRCCS Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articles Google scholar articles
Martin Oliverius Department of Surgery, Third Faculty of Medicine, University Hospital Kralovske Vinohrady, Charles University, Prague, Czech Republic PubMed articles Google scholar articles
Péter Jeno Hegyi Center for Traslational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Disease, Heart and Vascular Center, Semmelweis University, Budapest, Hungary PubMed articles Google scholar articles
Mara Goetz Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Pasquale Scognamiglio Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Andrea Mambrini Oncology of Massa Carrara, Oncological Department, Azienda USL Toscana Nord Ovest, Pisa, Italy PubMed articles Google scholar articles
Paolo Giorgio Arcidiacono Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Edita Kreivenaite Department of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articles Google scholar articles
Juozas Kupcinskas Department of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articles Google scholar articles
Tamas Hussein Center for Traslational Medicine, Semmelweis University, Budapest, Hungary Division of Pancreatic Disease, Heart and Vascular Center, Semmelweis University, Budapest, Hungary PubMed articles Google scholar articles
Stefano Ermini Blood Transfusion Service, Azienda Ospedaliero Universitaria Meyer, Firenze, Italy PubMed articles Google scholar articles
Anna Caterina Milanetto Department of Surgery-DiSCOG, Padua University Hospital, Padova, Italy PubMed articles Google scholar articles
Pavel Vodicka Department of Molecular Biology of Cancer, Institute of Experimental Medicine Czech Academy of Sciences, Prague, Czech Republic Biomedical Centre and Department of Surgery, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic First Faculty of Medicine, Institute of Biology and Medical Genetics, Charles University, Prague, Czech Republic PubMed articles Google scholar articles
Vytautas Kiudelis Department of Gastroenterology, Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articles Google scholar articles
Viktor Hlaváč Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic PubMed articles Google scholar articles
Pavel Soucek Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic PubMed articles Google scholar articles
George E Theodoropoulos First Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece PubMed articles Google scholar articles
Daniela Basso Department of Medicine-DIMED, Padua University Hospital, Padova, Italy PubMed articles Google scholar articles
John P Neoptolemos Department of General Surgery, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Mateus Nóbrega Aoki Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil PubMed articles Google scholar articles
Raffaele Pezzilli County Medical Association of Potenza, Potenza, Italy PubMed articles Google scholar articles
Claudio Pasquali Department of Surgery-DiSCOG, Padua University Hospital, Padova, Italy PubMed articles Google scholar articles
Roger Chammas Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil PubMed articles Google scholar articles
Sabrina Gloria Giulia Testoni Pancreato-Biliary Endoscopy and Endoscopic Ultrasound, Pancreas Translational and Clinical Research Center, IRSSC San Raffaele Scientific Institute, Milan, Italy PubMed articles Google scholar articles
Beatrice Mohelnikova-Duchonova Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic PubMed articles Google scholar articles
Maurizio Lucchesi Oncology of Massa Carrara, Oncological Department, Azienda USL Toscana Nord Ovest, Pisa, Italy PubMed articles Google scholar articles
Cosmeri Rizzato Department of Translational Research and new Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy PubMed articles Google scholar articles
Federico Canzian Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Daniele Campa Department of Biology, University of Pisa, Pisa, Italy PubMed articles Google scholar articles

Correspondence to Professor Daniele Campa, Department of Biology, University of Pisa, Pisa, Italy; daniele.campa{at}unipi.it

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Citation

Corradi C, Lencioni G, Gentiluomo M, et al

Polymorphic variants involved in methylation regulation: a strategy to discover risk loci for pancreatic ductal adenocarcinoma

Journal of Medical Genetics 2023;60:980-986.

Publication history

Received September 1, 2022
Accepted April 4, 2023
First published May 2, 2023.

Online issue publication

October 18, 2023

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