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Original research
Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects

Authors

  • Yoav Bolkier Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelMetabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Ortal Barel Genomic Unit, Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, IsraelThe Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Dina Marek-Yagel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelMetabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Danit Atias-Varon Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Maayan Kagan Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelPediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Amir Vardi Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Pediatric Cardiac Intensive Care, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • David Mishali Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Pediatric Cardiac Intensive Care, Edmond Safra International Congenital Heart Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Uriel Katz Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Yishay Salem Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Tal Tirosh-Wagner Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelSackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Jeffrey M Jacobson Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelPediatric Imaging Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Annick Raas-Rothschild Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThe Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Odelia Chorin Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThe Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Aviva Eliyahu Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThe Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Yarden Sarouf Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Omer Shlomovitz Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Alvit Veber Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Nechama Shalva Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Elisheva Javasky Genomic Unit, Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Yishay Ben Moshe Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Orna Staretz-Chacham Metabolic Clinic, Division of Pediatrics, Soroka Medical Center, Ben-Gurion University, Beer Sheva, Israel PubMed articlesGoogle scholar articles
  • Gideon Rechavi Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelThe Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, IsraelSheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Shrikant Mane Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Yair Anikster Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelMetabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelThe Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Asaf Vivante Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelDepartment of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelTalpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Ben Pode-Shakked Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, IsraelMetabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelDepartment of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, IsraelTalpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Ben Pode-Shakked, Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Ramat Gan, Israel; ben_pode{at}hotmail.com
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Citation

Bolkier Y, Barel O, Marek-Yagel D, et al
Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects

Publication history

  • Received February 9, 2021
  • Accepted June 19, 2021
  • First published July 2, 2021.

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