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Original research
Data sharing to improve concordance in variant interpretation across laboratories: results from the Canadian Open Genetics Repository

Authors

  • Chloe Mighton Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Ontario, CanadaPathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, CanadaLi Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, CanadaLunenfeld Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Amanda C Smith CHEO Research Institute, Ottawa, Ontario, Canada PubMed articlesGoogle scholar articles
  • Justin Mayers Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Robert Tomaszewski Alberta Precision Laboratories, Edmonton, Alberta, Canada PubMed articlesGoogle scholar articles
  • Sherryl Taylor Alberta Precision Laboratories, Edmonton, Alberta, CanadaMedical Genetics, University of Alberta, Edmonton, Alberta, Canada PubMed articlesGoogle scholar articles
  • Stacey Hume Alberta Precision Laboratories, Edmonton, Alberta, CanadaMedical Genetics, University of Alberta, Edmonton, Alberta, Canada PubMed articlesGoogle scholar articles
  • Ron Agatep Shared Health, Winnipeg, Manitoba, CanadaBiochemistry & Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada PubMed articlesGoogle scholar articles
  • Elizabeth Spriggs Shared Health, Winnipeg, Manitoba, CanadaBiochemistry & Medical Genetics, University of Manitoba, Winnipeg, Manitoba, Canada PubMed articlesGoogle scholar articles
  • Harriet E Feilotter Kingston Health Sciences Centre, Kingston, Ontario, CanadaDepartment of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada PubMed articlesGoogle scholar articles
  • Laura Semenuk Kingston Health Sciences Centre, Kingston, Ontario, Canada PubMed articlesGoogle scholar articles
  • Henry Wong Kingston Health Sciences Centre, Kingston, Ontario, Canada PubMed articlesGoogle scholar articles
  • Lorena Lazo de la Vega Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, Massachusetts, USADepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Christian R Marshall Genome Diagnostics, The Hospital for Sick Children, Toronto, Ontario, CanadaLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Michelle M Axford Genome Diagnostics, The Hospital for Sick Children, Toronto, Ontario, CanadaLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Talia Silver Genome Diagnostics, The Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • George S Charames Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, CanadaLunenfeld Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, CanadaLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Vanessa Di Gioacchino Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Nicholas Watkins Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, CanadaDepartment of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • William D Foulkes Departments of Oncology and Human Genetics, McGill University, Montreal, Quebec, CanadaLady David Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Marcos Clavier Lady David Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Nancy Hamel Research Institute of the McGill University Health Centre, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • George Chong Lady David Institute for Medical Research, Jewish General Hospital, Montreal, Quebec, CanadaDepartment of Human Genetics, McGill University, Montreal, Quebec, Canada PubMed articlesGoogle scholar articles
  • Ryan E Lamont Department of Medical Genetics, University of Calgary, Calgary, Alberta, CanadaAlberta Precision Laboratories, Calgary, Alberta, Canada PubMed articlesGoogle scholar articles
  • Jillian Parboosingh Department of Medical Genetics, University of Calgary, Calgary, Alberta, CanadaAlberta Precision Laboratories, Calgary, Alberta, Canada PubMed articlesGoogle scholar articles
  • Aly Karsan Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Ian Bosdet Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, CanadaBC Cancer Agency, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Sean S Young Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, CanadaBC Cancer Agency, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Tracy Tucker Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, CanadaBC Cancer Agency, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Mohammad Reza Akbari Women's College Research Institute, Women's College Hospital, Toronto, Ontario, CanadaInstitute of Medical Science, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Marsha D Speevak Trillium Health Partners, Mississauga, Ontario, Canada PubMed articlesGoogle scholar articles
  • Andrea K Vaags Trillium Health Partners, Mississauga, Ontario, Canada PubMed articlesGoogle scholar articles
  • Matthew S Lebo Laboratory for Molecular Medicine, Mass General Brigham Personalized Medicine, Cambridge, Massachusetts, USADepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Jordan Lerner-Ellis Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, CanadaLunenfeld Tanenbaum Research Institute, Sinai Health, Toronto, Ontario, CanadaLaboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Canadian Open Genetics Repository Working Group
    Google scholar articles
  1. Correspondence to Dr Jordan Lerner-Ellis, Pathology and Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, ON M5G 1X5, Canada; jordan.lerner-ellis{at}sinaihealth.ca
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Citation

Mighton C, Smith AC, Mayers J Canadian Open Genetics Repository Working Group, et al
Data sharing to improve concordance in variant interpretation across laboratories: results from the Canadian Open Genetics Repository

Publication history

  • Received January 25, 2021
  • Revised March 22, 2021
  • Accepted March 25, 2021
  • First published April 19, 2021.

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