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Original research
High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer

Authors

  • D Gareth Evans Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKPrevent Breast Cancer Centre, Wythenshawe Hospital Manchester, University NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  • Elke Maria van Veen Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Helen J Byers Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Sarah J Evans Division of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UKDepartment of Histopathology, Manchester University Hospitals NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  • George J Burghel Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK PubMed articlesGoogle scholar articles
  • Emma Roisin Woodward Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Elaine F Harkness Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester, University NHS Foundation Trust, Manchester, UKDivision of Informatics, Imaging and Data Sciences, School of Health Sciences, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Diana M Eccles University of Southampton and University Hospital Southampton, Southampton, UK PubMed articlesGoogle scholar articles
  • Stephanie L Greville-Haygate University of Southampton and University Hospital Southampton, Southampton, UK PubMed articlesGoogle scholar articles
  • Jamie M Ellingford Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Naomi L Bowers Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK PubMed articlesGoogle scholar articles
  • Marta Pereira Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK PubMed articlesGoogle scholar articles
  • Andrew J Wallace Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK PubMed articlesGoogle scholar articles
  • Sasha J Howell Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester, University NHS Foundation Trust, Manchester, UKDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Anthony Howell Prevent Breast Cancer Centre, Wythenshawe Hospital Manchester, University NHS Foundation Trust, Manchester, UKDivision of Cancer Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Fiona Lalloo Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK PubMed articlesGoogle scholar articles
  • William G Newman Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Miriam Jane Smith Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UKDivision of Evolution and Genomic Sciences, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor D Gareth Evans, Manchester Centre for Genomic Medicine, Manchester Academic Health Sciences Centre (MAHSC), St Mary’s Hospital, University of Manchester, Manchester, UK; gareth.evans{at}mft.nhs.uk
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Citation

Evans DG, van Veen EM, Byers HJ, et al
High likelihood of actionable pathogenic variant detection in breast cancer genes in women with very early onset breast cancer

Publication history

  • Received July 17, 2020
  • Revised October 27, 2020
  • Accepted October 31, 2020
  • First published March 23, 2021.
  • Supplementary Data

    This web only file has been produced by the BMJ Publishing Group from an electronic file supplied by the author(s) and has not been edited for content.

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