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- Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction
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Genotype-phenotype correlations
Original research
Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction

Authors
- Alice Alessandra Galeotti Department of Biology, University of Pisa, Pisa, ItalyGenomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
- Manuel Gentiluomo Department of Biology, University of Pisa, Pisa, Italy PubMed articlesGoogle scholar articles
- Cosmeri Rizzato Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, GermanyDepartment of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy PubMed articlesGoogle scholar articles
- Ofure Obazee Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
- John P Neoptolemos Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
- Claudio Pasquali Pancreatic and Endocrine Surgical Unit, University of Padova, Padova, Italy PubMed articlesGoogle scholar articles
- Michael Nentwich Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
- Giulia Martina Cavestro Gastroenterology and Gastrointestinal Endoscopy Unit, Vita-Salute San Raffaele University, San Raffaele Scientific Institute, Milano, Italy PubMed articlesGoogle scholar articles
- Raffaele Pezzilli Department of Gastroenterology, Polyclinic of Sant’Orsola, Bologna, Italy PubMed articlesGoogle scholar articles
- William Greenhalf Institute for Health Research, Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
- Bernd Holleczek Saarland Cancer Registry, Saarbrücken, GermanyDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
- Cornelia Schroeder Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
- Ben Schöttker Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyNetwork Aging Research, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
- Audrius Ivanauskas Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articlesGoogle scholar articles
- Laura Ginocchi Oncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy PubMed articlesGoogle scholar articles
- Timothy J Key Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK PubMed articlesGoogle scholar articles
- Péter Hegyi Institute for Translational Medicine, Medical School, University of Pécs, Pécs, HungaryFirst Department of Medicine, University of Szeged, Szeged, Hungary PubMed articlesGoogle scholar articles
- Livia Archibugi Digestive and Liver Disease Unit, S. Andrea Hospital, S. Andrea Hospital ‘Sapienza’ University of Rome, Rome, ItalyPancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milano, Italy PubMed articlesGoogle scholar articles
- Erika Darvasi First Department of Medicine, University of Szeged, Szeged, Hungary PubMed articlesGoogle scholar articles
- Daniela Basso Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy PubMed articlesGoogle scholar articles
- Cosimo Sperti Third Surgical Clinic - Department of Surgery, Oncology and Gastroenterology (DiSCOG), University of Padua, Padova, Italy PubMed articlesGoogle scholar articles
- Maarten F Bijlsma Laboratory for Experimental Oncology and Radiobiology Center for Experimental and Molecular Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The NetherlandsCancer Center Amsterdam, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Orazio Palmieri Division of Gastroenterology and Research Laboratory, Department of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articlesGoogle scholar articles
- Viktor Hlavac Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic PubMed articlesGoogle scholar articles
- Renata Talar-Wojnarowska Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland PubMed articlesGoogle scholar articles
- Beatrice Mohelnikova-Duchonova Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic PubMed articlesGoogle scholar articles
- Thilo Hackert Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
- Yogesh Vashist Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
- Ondrej Strouhal Department of Oncology, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech RepublicInstitute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University Olomouc, Olomouc, Czech Republic PubMed articlesGoogle scholar articles
- Hanneke van Laarhoven Cancer Center Amsterdam, Amsterdam, The NetherlandsDepartment of Medical Oncology, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands PubMed articlesGoogle scholar articles
- Francesca Tavano Division of Gastroenterology and Research Laboratory, Department of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articlesGoogle scholar articles
- Martin Lovecek Department of Surgery I, Faculty of Medicine and Dentistry, Palacky University Olomouc and University Hospital Olomouc, Olomouc, Czech Republic PubMed articlesGoogle scholar articles
- Christos Dervenis Department of Surgical Oncology and HPB Surgery, University of Cyprus, Nicosia, Cyprus PubMed articlesGoogle scholar articles
- Ferenc Izbéki Szent György University Teaching Hospital of Fejér County, Székesfehérvár, Hungary PubMed articlesGoogle scholar articles
- Andrea Padoan Department of Laboratory Medicine, University-Hospital of Padova, Padova, Italy PubMed articlesGoogle scholar articles
- Ewa Małecka-Panas Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland PubMed articlesGoogle scholar articles
- Evaristo Maiello Division of Gastroenterology and Research Laboratory, Department of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articlesGoogle scholar articles
- Giuseppe Vanella Digestive and Liver Disease Unit, S. Andrea Hospital, S. Andrea Hospital ‘Sapienza’ University of Rome, Rome, Italy PubMed articlesGoogle scholar articles
- Gabriele Capurso Digestive and Liver Disease Unit, S. Andrea Hospital, S. Andrea Hospital ‘Sapienza’ University of Rome, Rome, ItalyPancreato-Biliary Endoscopy and EUS Division, Pancreas Translational and Clinical Research Center, San Raffaele Scientific Institute IRCCS, Milano, Italy PubMed articlesGoogle scholar articles
- Jakob R Izbicki Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articlesGoogle scholar articles
- George E Theodoropoulos First Propaedeutic University Surgery Clinic, Hippocratio General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece PubMed articlesGoogle scholar articles
- Krzysztof Jamroziak Department of Hematology, Institute of Hematology and Transfusion Medicine, Warsaw, Poland PubMed articlesGoogle scholar articles
- Verena Katzke Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
- Rudolf Kaaks Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
- Andrea Mambrini Oncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy PubMed articlesGoogle scholar articles
- Ioannis S Papanikolaou Second Department of Internal Medicine and Research Unit, "Attikon" University General Hospital, Medical School, National and Kapodistrian University of Athens, Athens, Greece PubMed articlesGoogle scholar articles
- Richárd Szmola Department of Interventional Gastroenterology, National Institute of Oncology, Budapest, Hungary PubMed articlesGoogle scholar articles
- Andrea Szentesi Institute for Translational Medicine, Medical School, University of Pécs, Pécs, HungaryFirst Department of Medicine, University of Szeged, Szeged, Hungary PubMed articlesGoogle scholar articles
- Juozas Kupcinskas Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania PubMed articlesGoogle scholar articles
- Simona Bursi Oncological Department, Azienda USL Toscana Nord Ovest, Oncological Unit of Massa Carrara, Carrara, Italy PubMed articlesGoogle scholar articles
- Eithne Costello Institute for Health Research, Liverpool Pancreas Biomedical Research Unit, University of Liverpool, Liverpool, UK PubMed articlesGoogle scholar articles
- Ugo Boggi Division of General and Transplant Surgery, Pisa University Hospital, Pisa, Italy PubMed articlesGoogle scholar articles
- Anna Caterina Milanetto Pancreatic and Endocrine Surgical Unit, University of Padova, Padova, Italy PubMed articlesGoogle scholar articles
- Stefano Landi Department of Biology, University of Pisa, Pisa, Italy PubMed articlesGoogle scholar articles
- Maria Gazouli Laboratory of Biology, Medical School, National and Kapodistrian University of Athens, Athens, Greece PubMed articlesGoogle scholar articles
- Ludmila Vodickova Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech RepublicInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech RepublicBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic PubMed articlesGoogle scholar articles
- Pavel Soucek Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic PubMed articlesGoogle scholar articles
- Domenica Gioffreda Division of Gastroenterology and Research Laboratory, Department of Oncology, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy PubMed articlesGoogle scholar articles
- Federica Gemignani Department of Biology, University of Pisa, Pisa, Italy PubMed articlesGoogle scholar articles
- Hermann Brenner Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, GermanyDivision of Preventive Oncology, German Cancer Research Center (DKFZ) and National Center for Tumor Diseases (NCT), Heidelberg, GermanyGerman Cancer Consortium (DKTK), German Cancer Research Center (DKFZ) Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
- Oliver Strobel Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
- Markus Büchler Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Heidelberg, Germany PubMed articlesGoogle scholar articles
- Pavel Vodicka Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech RepublicInstitute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech RepublicBiomedical Centre, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic PubMed articlesGoogle scholar articles
- Salvatore Paiella General and Pancreatic Surgery Department, Pancreas Institute, University of Verona, Verona, Italy PubMed articlesGoogle scholar articles
- Federico Canzian Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articlesGoogle scholar articles
- Daniele Campa Department of Biology, University of Pisa, Pisa, Italy PubMed articlesGoogle scholar articles
- Correspondence to Dr Federico Canzian, Genome Epidemiology, German Cancer Research Center (DKFZ), Heidelberg 69120, Germany; f.canzian{at}dkfz.de
Citation
Galeotti AA, Gentiluomo M, Rizzato C, et al
Polygenic and multifactorial scores for pancreatic ductal adenocarcinoma risk prediction
Journal of Medical Genetics Published Online First: 26 June 2020. doi: 10.1136/jmedgenet-2020-106961
Publication history
- Received February 26, 2020
- Revised April 20, 2020
- Accepted May 9, 2020
- First published June 26, 2020.
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© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.