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  • A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium

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Original article
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium
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Authors

  • Raymond Noordam Department of Epidemiology, Erasmus MC—University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Colleen M Sitlani Department of Medicine, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Christy L Avery Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • James D Stewart Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Stephanie M Gogarten Department of Biostatistics, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Kerri L Wiggins Department of Medicine, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Stella Trompet Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Helen R Warren Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Fangui Sun Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Daniel S Evans California Pacific Medical Center Research Institute, San Francisco, California, USA PubMed articlesGoogle scholar articles
  • Xiaohui Li Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA PubMed articlesGoogle scholar articles
  • Jin Li Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Palo Alto, California, USA PubMed articlesGoogle scholar articles
  • Albert V Smith Icelandic Heart Association, Kopavogur, Iceland Faculty of Medicine, University of Iceland, Reykavik, Iceland PubMed articlesGoogle scholar articles
  • Joshua C Bis Department of Medicine, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Jennifer A Brody Department of Medicine, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Evan L Busch Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Mark J Caulfield Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Yii-Der I Chen Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA PubMed articlesGoogle scholar articles
  • Steven R Cummings California Pacific Medical Center Research Institute, San Francisco, California, USA PubMed articlesGoogle scholar articles
  • L Adrienne Cupples Department of Biostatistics, School of Public Health, Boston University, Boston, Massachusetts, USA Framingham Heart Study, Framingham, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Qing Duan Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Oscar H Franco Department of Epidemiology, Erasmus MC—University Medical Center Rotterdam, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Rául Méndez-Giráldez Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Tamara B Harris Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Susan R Heckbert Department of Epidemiology, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Diana van Heemst Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Albert Hofman Department of Epidemiology, Erasmus MC—University Medical Center Rotterdam, Rotterdam, The Netherlands Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • James S Floyd Department of Medicine, University of Washington, Seattle, Washington, USA Department of Epidemiology, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Jan A Kors Department of Medical Informatics, Erasmus MC—University Medical Center Rotterdam, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Lenore J Launer Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland, USA PubMed articlesGoogle scholar articles
  • Yun Li Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA Department of Computer Science, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Ruifang Li-Gao Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Leslie A Lange Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Henry J Lin Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California, USA PubMed articlesGoogle scholar articles
  • Renée de Mutsert Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Melanie D Napier Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Christopher Newton-Cheh Framingham Heart Study, Framingham, Massachusetts, USA Cardiovascular Research Center & Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Neil Poulter International Centre for Circulatory Health, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Alexander P Reiner Department of Epidemiology, University of Washington, Seattle, Washington, USA Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Kenneth M Rice Department of Biostatistics, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Jeffrey Roach Research Computing Center, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Carlos J Rodriguez Department of Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA Department of Epidemiology and Prevention, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • Frits R Rosendaal Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Naveed Sattar Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, Glasgow, UK PubMed articlesGoogle scholar articles
  • Peter Sever International Centre for Circulatory Health, Imperial College London, London, UK PubMed articlesGoogle scholar articles
  • Amanda A Seyerle Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • P Eline Slagboom Department of Medical Statistics and Bioinformatics, Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Elsayed Z Soliman Epidemiological Cardiology Research Center (EPICARE), Wake Forest School of Medicine, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • Nona Sotoodehnia Department of Medicine, University of Washington, Seattle, Washington, USA Department of Epidemiology, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • David J Stott Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK PubMed articlesGoogle scholar articles
  • Til Stürmer Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA Center of Pharmacoepidemiology, Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Kent D Taylor Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA PubMed articlesGoogle scholar articles
  • Timothy A Thornton Department of Biostatistics, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • André G Uitterlinden Department of Internal Medicine, Erasmus MC—University Medical Center Rotterdam, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Kirk C Wilhelmsen Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA The Renaissance Computing Institute, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • James G Wilson Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi, USA PubMed articlesGoogle scholar articles
  • Vilmundur Gudnason Icelandic Heart Association, Kopavogur, Iceland Faculty of Medicine, University of Iceland, Reykavik, Iceland PubMed articlesGoogle scholar articles
  • J Wouter Jukema Department of Cardiology, Leiden University Medical Center, Leiden, The Netherlands Durrer Center for Cardiogenetic Research, Amsterdam, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Cathy C Laurie Department of Biostatistics, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Yongmei Liu Division of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, USA PubMed articlesGoogle scholar articles
  • Dennis O Mook-Kanamori Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands Department of BESC, Epidemiology Section, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia PubMed articlesGoogle scholar articles
  • Patricia B Munroe Department of Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine, Queen Mary University of London, London, UK NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine, Queen Mary University of London, London, UK PubMed articlesGoogle scholar articles
  • Jerome I Rotter Institute for Translational Genomics and Population Sciences and Department of Pediatrics, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA PubMed articlesGoogle scholar articles
  • Ramachandran S Vasan Framingham Heart Study, Framingham, Massachusetts, USA Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Bruce M Psaty Department of Medicine, University of Washington, Seattle, Washington, USA Department of Epidemiology, University of Washington, Seattle, Washington, USA Department of Health Services, University of Washington, Seattle, Washington, USA Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Bruno H Stricker Department of Epidemiology, Erasmus MC—University Medical Center Rotterdam, Rotterdam, The Netherlands Inspectorate of Health Care, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Eric A Whitsel Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina, USA Department of Medicine, University of North Carolina, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr. Bruno H Stricker, Department of Epidemiology, Erasmus MC - University Medical Center Rotterdam, P.O. Box 2040, 3000 CA, Rotterdam, The Netherlands; b.stricker{at}erasmusmc.nl
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Citation

Noordam R, Sitlani CM, Avery CL, et al
A genome-wide interaction analysis of tricyclic/tetracyclic antidepressants and RR and QT intervals: a pharmacogenomics study from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium
Journal of Medical Genetics 2017;54:313-323.

Publication history

  • Received July 10, 2016
  • Revised November 11, 2016
  • Accepted December 6, 2016
  • First published December 30, 2016.
Online issue publication 
April 26, 2017

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