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The IRF5 polymorphism in type 1 diabetes
  1. Hui-Qi Qu (hui.qi.qu{at}mail.mcgill.ca)
  1. The McGill University Health Center, Canada
    1. Luc Marchand (luc.marchand{at}gmail.com)
    1. The McGill University Health Center, Canada
      1. Rosemary Grabs (rosemary.grabs{at}muhc.mcgill.ca)
      1. The McGill University Health Center, Canada
        1. Constantin Polychronakos (constantin.polychronakos{at}mcgill.ca)
        1. The McGill University Health Center, Canada

          Abstract

          The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increasd IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 type 1diabetes (T1D) nuclear family trios by the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer obvious risk to T1D.

          • genetic association
          • interferon regulatory factor 5
          • systemic lupus erythematosus
          • transmission disequilibrium test
          • type 1 diabetes

          https://doi.org/10.1136/jmg.2007.050971

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