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Novel disease loci
Original research
NASP gene contributes to autism by epigenetic dysregulation of neural and immune pathways

Authors

  • Sipeng Zhang Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Jie Yang Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Dandan Ji Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Xinyi Meng Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Chonggui Zhu Department of Endocrinology, Tianjin Medical University General Hospital, Tianjin, China PubMed articlesGoogle scholar articles
  • Gang Zheng National Supercomputer Center in Tianjin (NSCC-TJ), Tianjin, China PubMed articlesGoogle scholar articles
  • Joseph Glessner Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA PubMed articlesGoogle scholar articles
  • Hui-Qi Qu Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA PubMed articlesGoogle scholar articles
  • Yuechen Cui Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Yichuan Liu Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA PubMed articlesGoogle scholar articles
  • Wei Wang The Institute of Psychology of the Chinese Academy of Sciences, Beijing, China PubMed articlesGoogle scholar articles
  • Xiumei Li Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Hao Zhang Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Zhanjie Xiu Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China Department of Bioinformatics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Yan Sun Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Ling Sun Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Jie Li Laboratory of Biological Psychiatry, Institute of Mental Health, Tianjin Anding Hospital, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  • Hakon Hakonarson Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, PA, USA Division of Human Genetics, Children’s Hospital of Philadelphia, Philadelphia, PA, USA Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA PubMed articlesGoogle scholar articles
  • Jin Li Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China Department of Rheumatology and Immunology, Tianjin Medical University General Hospital, Tianjin, China PubMed articlesGoogle scholar articles
  • Qianghua Xia Department of Cell Biology, The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Key Laboratory of Medical Epigenetics, Tianjin Institute of Immunology, Tianjin Key Laboratory of Birth Defects for Prevention and Treatment, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China Department of Bioinformatics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Jin Li, Department of Cell Biology, Tianjin Medical University, Tianjin, China; jli01{at}tmu.edu.cn; Dr Qianghua Xia, Department of Bioinformatics, Tianjin Medical University, Tianjin, China; qhxia{at}tmu.edu.cn
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Citation

Zhang S, Yang J, Ji D, et al
NASP gene contributes to autism by epigenetic dysregulation of neural and immune pathways
Journal of Medical Genetics 2024;61:677-688.

Publication history

  • Received May 9, 2023
  • Accepted February 21, 2024
  • First published March 5, 2024.
Online issue publication 
June 20, 2024

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© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ.