Lynch syndrome diagnostic testing pathways in endometrial cancers: a nationwide English registry-based study

Lucy Loong; Catherine Huntley; Joanna Pethick; Fiona McRonald; Francesco Santaniello; Brian Shand; Oliver Tulloch; Shilpi Goel; Margreet Lüchtenborg; Sophie Allen; Bethany Torr; Katie Snape; Angela George; Fiona Lalloo; Gail Norbury; Diana M Eccles; Marc Tischkowitz; Antonis C Antoniou; Paul Pharoah; Adam Shaw; Eva Morris; John Burn; Kevin Monahan; Steven Hardy; Clare Turnbull

doi:10.1136/jmg-2024-110231

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Cancer genetics

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Lynch syndrome diagnostic testing pathways in endometrial cancers: a nationwide English registry-based study

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Lucy Loong Institute of Cancer Research Division of Genetics and Epidemiology, Sutton, UK National Disease Registration Service, London, UK PubMed articles Google scholar articles
Catherine Huntley Institute of Cancer Research Division of Genetics and Epidemiology, Sutton, UK National Disease Registration Service, London, UK PubMed articles Google scholar articles
Joanna Pethick National Disease Registration Service, London, UK PubMed articles Google scholar articles
Fiona McRonald National Disease Registration Service, London, UK PubMed articles Google scholar articles
Francesco Santaniello National Disease Registration Service, London, UK Health Data Insight, Cambridge, UK PubMed articles Google scholar articles
Brian Shand National Disease Registration Service, London, UK PubMed articles Google scholar articles
Oliver Tulloch National Disease Registration Service, London, UK PubMed articles Google scholar articles
Shilpi Goel National Disease Registration Service, London, UK Health Data Insight, Cambridge, UK PubMed articles Google scholar articles
Margreet Lüchtenborg National Disease Registration Service, London, UK Cancer Epidemiology and Cancer Services Research, Centre for Cancer, Society & Public Health, Comprehensive Cancer Centre, King's College London, London, UK PubMed articles Google scholar articles
Sophie Allen Institute of Cancer Research Division of Genetics and Epidemiology, Sutton, UK National Disease Registration Service, London, UK PubMed articles Google scholar articles
Bethany Torr Institute of Cancer Research Division of Genetics and Epidemiology, Sutton, UK PubMed articles Google scholar articles
Katie Snape Department of Clinical Genetics, St George's University Hospitals NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Angela George Gynaecology Unit, Royal Marsden NHS Foundation Trust, London, UK The Institute of Cancer Research—Sutton, London, UK PubMed articles Google scholar articles
Fiona Lalloo Clinical Genetics Service, Manchester Centre for Genomic Medicine, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK PubMed articles Google scholar articles
Gail Norbury South East Genomic Laboratory Hub, Guy's and St Thomas' Hospitals NHS Trust, London, UK PubMed articles Google scholar articles
Diana M Eccles Human Genetics and Genomic Medicine, University of Southampton Faculty of Medicine, Southampton, UK PubMed articles Google scholar articles
Marc Tischkowitz Department of Medical Genetics, Cambridge Biomedical Research Centre, National Institute for Health Research, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Antonis C Antoniou Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK PubMed articles Google scholar articles
Paul Pharoah Department of Computational Biomedicine, Cedars-Sinai Medical Center, Los Angeles, California, USA PubMed articles Google scholar articles
Adam Shaw Department of Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK PubMed articles Google scholar articles
Eva Morris Applied Health Research Unit, Big Data Institute, Nuffield Department of Population Health, University of Oxford, Oxford, UK PubMed articles Google scholar articles
John Burn Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK PubMed articles Google scholar articles
Kevin Monahan The Lynch Syndrome and Family Cancer Clinic, St Mark's Hospital and Academic Institute, London, UK Imperial College London, London, UK PubMed articles Google scholar articles
Steven Hardy National Disease Registration Service, London, UK PubMed articles Google scholar articles
Clare Turnbull Institute of Cancer Research Division of Genetics and Epidemiology, Sutton, UK National Disease Registration Service, London, UK PubMed articles Google scholar articles

Correspondence to Professor Clare Turnbull; turnbull.lab{at}icr.ac.uk

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Loong L, Huntley C, Pethick J, et al

Lynch syndrome diagnostic testing pathways in endometrial cancers: a nationwide English registry-based study

Journal of Medical Genetics 2024;61:1080-1088.

Publication history

Received July 11, 2024
Accepted September 18, 2024
First published October 21, 2024.

Online issue publication

November 25, 2024

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© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.

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