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A model for the return and referral of all clinically significant secondary findings of genomic sequencing

Authors

  • Rita Kodida Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Emma Reble Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Marc Clausen Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Salma Shickh Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Chloe Mighton Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Jordan Sam Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Nicole Forster Fred A. Litwin Family Centre in Genetic Medicine, University Health Network, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Seema Panchal The Marvelle Koffler Breast Centre, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Melyssa Aronson Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Kara Semotiuk Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Tracy Graham Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Yael Silberman Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Susan Randall Armel Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Division of Medical Oncology & Hematology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Jeanna M McCuaig Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Division of Medical Oncology & Hematology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Iris Cohn Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Chantal F Morel Fred A. Litwin Family Centre in Genetic Medicine, University Health Network, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Christine Elser The Marvelle Koffler Breast Centre, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Andrea Eisen Odette Cancer Centre, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • June C Carroll Department of Family & Community Medicine, University of Toronto, Toronto, Ontario, Canada Granovsky Gluskin Family Medicine Centre, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Emily Glogowski GeneDx, Gaithersburg, Maryland, USA PubMed articlesGoogle scholar articles
  • Kasmintan A Schrader British Columbia Cancer Agency, Vancouver, British Columbia, Canada Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada PubMed articlesGoogle scholar articles
  • Vanessa Di Gioacchino The Marvelle Koffler Breast Centre, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada Pathology & Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Jordan Lerner-Ellis Pathology & Laboratory Medicine, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, Sinai Health, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Raymond H Kim Division of Medical Oncology & Hematology, Princess Margaret Hospital Cancer Centre, Toronto, Ontario, Canada Department of Medicine, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • Yvonne Bombard Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada Institute of Health Policy, Management & Evaluation, University of Toronto, Toronto, Ontario, Canada PubMed articlesGoogle scholar articles
  • on behalf of the Incidental Genomics Study Team
    Google scholar articles
  1. Correspondence to Dr Yvonne Bombard, Genomics Health Services & Policy Research Program, Li Ka Shing Knowledge Institute, St Michael's Hospital, Unity Health Toronto, Toronto, ON M5B 1W8, Canada; yvonne.bombard{at}utoronto.ca
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Citation

Kodida R, Reble E, Clausen M on behalf of the Incidental Genomics Study Team, et al
A model for the return and referral of all clinically significant secondary findings of genomic sequencing
Journal of Medical Genetics 2023;60:733-739.

Publication history

  • Received December 5, 2022
  • Accepted April 19, 2023
  • First published May 22, 2023.
Online issue publication 
July 21, 2023

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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.