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Cancer genetics
Original research
Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome

Authors

  • Nuria Dueñas Hereditary Cancer Program, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Spain Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Oncology (CIBERONC), Instituto Salud Carlos III, Madrid, Spain European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Nijmegen, Netherlands PubMed articlesGoogle scholar articles
  • Hannah Klinkhammer Institute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Nuria Bonifaci Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Oncology (CIBERONC), Instituto Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Isabel Spier European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Nijmegen, Netherlands Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany National Center for Hereditary Tumor Syndromes, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Andreas Mayr Institute for Medical Biometry, Informatics and Epidemiology, Medical Faculty, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Emadeldin Hassanin Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg PubMed articlesGoogle scholar articles
  • Anna Diez-Villanueva Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Spain Colorectal Cancer Group (ONCOBELL), Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L’Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Instituto Salud Carlos III, Madrid, Spain PubMed articlesGoogle scholar articles
  • Victor Moreno Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology - ICO, L'Hospitalet de Llobregat, Spain Colorectal Cancer Group (ONCOBELL), Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L’Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Epidemiology and Public Health (CIBERESP), Instituto Salud Carlos III, Madrid, Spain Department of Clinical Sciences, Faculty of Medicine and Health Sciences and Universitat de Barcelona Institute of Complex Systems (UBICS), Universitat de Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Marta Pineda Hereditary Cancer Program, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Spain Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Oncology (CIBERONC), Instituto Salud Carlos III, Madrid, Spain European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Nijmegen, Netherlands PubMed articlesGoogle scholar articles
  • Carlo Maj Institute for Genomic Statistics and Bioinformatics, Medical Faculty, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Gabriel Capellà Hereditary Cancer Program, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Spain Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Oncology (CIBERONC), Instituto Salud Carlos III, Madrid, Spain European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Nijmegen, Netherlands PubMed articlesGoogle scholar articles
  • Stefan Aretz European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Nijmegen, Netherlands Institute of Human Genetics, Medical Faculty, University of Bonn, Bonn, Germany National Center for Hereditary Tumor Syndromes, University of Bonn, Bonn, Germany PubMed articlesGoogle scholar articles
  • Joan Brunet Hereditary Cancer Program, Catalan Institute of Oncology - ICO, L’Hospitalet de Llobregat, Spain Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge - IDIBELL, L'Hospitalet de Llobregat, Spain Biomedical Research Centre Network for Oncology (CIBERONC), Instituto Salud Carlos III, Madrid, Spain European Reference Network on Genetic Tumour Risk Syndromes (ERN GENTURIS), Nijmegen, Netherlands Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Girona, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Joan Brunet, Hereditary Cancer Program, Catalan Institute of Oncology, Girona 17190, Spain; jbrunet{at}iconcologia.net; Professor Stefan Aretz; stefan.aretz{at}uni-bonn.de
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Citation

Dueñas N, Klinkhammer H, Bonifaci N, et al
Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome
Journal of Medical Genetics 2023;60:1044-1051.

Publication history

  • Received April 21, 2023
  • Accepted May 12, 2023
  • First published June 15, 2023.
Online issue publication 
October 24, 2023

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© Author(s) (or their employer(s)) 2023. No commercial re-use. See rights and permissions. Published by BMJ.