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Gametes
Original research
Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice

Authors

  • Jiangshan Cong Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  • Xiong Wang Department of Surgery, Medical College of Shandong University, Jinan, Shandong, China Reproductive Medicine Center, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China PubMed articlesGoogle scholar articles
  • Amir Amiri-Yekta Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research, Tehran, Iran Université Grenoble Alpes, Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Grenoble, France PubMed articlesGoogle scholar articles
  • Lingbo Wang Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  • Zine-Eddine Kherraf Université Grenoble Alpes, Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Grenoble, France Centre Hospitalier Universitaire de Grenoble, UM GI-DPI, Grenoble, France PubMed articlesGoogle scholar articles
  • Chunyu Liu Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  • Caroline Cazin Université Grenoble Alpes, Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Grenoble, France Centre Hospitalier Universitaire de Grenoble, UM GI-DPI, Grenoble, France Laboratoire Eurofins Biomnis, Lyon, France PubMed articlesGoogle scholar articles
  • Shuyan Tang Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  • Seyedeh Hanieh Hosseini Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research, Tehran, Iran PubMed articlesGoogle scholar articles
  • Shixiong Tian Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  • Abbas Daneshipour Department of Genetics, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, Academic Center for Education, Culture, and Research, Tehran, Iran PubMed articlesGoogle scholar articles
  • Jiaxiong Wang State Key Laboratory of Reproductive Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China Suzhou Municipal Hospital, Suzhou, Jiangsu, China PubMed articlesGoogle scholar articles
  • Yiling Zhou Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  • Yuyan Zeng Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Shenmin Yang State Key Laboratory of Reproductive Medicine, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China Suzhou Municipal Hospital, Suzhou, Jiangsu, China PubMed articlesGoogle scholar articles
  • Xiaojin He Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Jinsong Li State Key Laboratory of Cell Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China University of the Chinese Academy of Sciences, Shangai, China PubMed articlesGoogle scholar articles
  • Yunxia Cao Reproductive Medicine Center, Department of Obstetrics and Gynecology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, Anhui Medical University, Hefei, Anhui, China MOE Key Laboratory of Population Health Across Life Cycle, Anhui Medical University, Hefei, Anhui, China PubMed articlesGoogle scholar articles
  • Li Jin Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China PubMed articlesGoogle scholar articles
  • Pierre F Ray Université Grenoble Alpes, Genetic Epigenetic and Therapies of Infertility, Institute for Advanced Biosciences, INSERM U1209, CNRS UMR 5309, Grenoble, France Centre Hospitalier Universitaire de Grenoble, UM GI-DPI, Grenoble, France PubMed articlesGoogle scholar articles
  • Feng Zhang Obstetrics and Gynecology Hospital, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute for Biomedical and Pharmaceutical Technologies), State Key Laboratory of Genetic Engineering at School of Life Sciences, Fudan University, Shanghai, China Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China PubMed articlesGoogle scholar articles
  1. Correspondence to Professor Feng Zhang, Fudan University, Shanghai, China; zhangfeng{at}fudan.edu.cn; Professor Pierre F Ray, Université Grenoble Alpes, Grenoble, France; pray{at}chu-grenoble.fr
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Citation

Cong J, Wang X, Amiri-Yekta A, et al
Homozygous mutations in CCDC34 cause male infertility with oligoasthenoteratozoospermia in humans and mice
Journal of Medical Genetics 2022;59:710-718.

Publication history

  • Received April 13, 2021
  • Accepted July 14, 2021
  • First published August 4, 2021.
Online issue publication 
June 27, 2022

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© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.