You are here

  • Home
  • Archive
  • Volume 59, Issue 7
  • Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects

Article info

Article menu
Download PDFPDF
Developmental defects
Original research
Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects

Authors

  • Yoav Bolkier Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Ortal Barel Genomic Unit, Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel The Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Dina Marek-Yagel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Danit Atias-Varon Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Maayan Kagan Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Pediatric Nephrology Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Amir Vardi Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Pediatric Cardiac Intensive Care, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • David Mishali Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Pediatric Cardiac Intensive Care, Edmond Safra International Congenital Heart Center, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Uriel Katz Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Yishay Salem Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Tal Tirosh-Wagner Pediatric Heart Institute, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel PubMed articlesGoogle scholar articles
  • Jeffrey M Jacobson Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Pediatric Imaging Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Annick Raas-Rothschild Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel The Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Odelia Chorin Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel The Institute of Rare Diseases, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Aviva Eliyahu Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel The Danek Gertner Institute of Human Genetics, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Yarden Sarouf Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Omer Shlomovitz Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Alvit Veber Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Nechama Shalva Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Elisheva Javasky Genomic Unit, Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Yishay Ben Moshe Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Orna Staretz-Chacham Metabolic Clinic, Division of Pediatrics, Soroka Medical Center, Ben-Gurion University, Beer Sheva, Israel PubMed articlesGoogle scholar articles
  • Gideon Rechavi Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel The Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Israel Sheba Cancer Research Center, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Shrikant Mane Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA PubMed articlesGoogle scholar articles
  • Yair Anikster Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel The Wohl Institute for Translational Medicine, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Asaf Vivante Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  • Ben Pode-Shakked Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Department of Pediatrics B, Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel Talpiot Medical Leadership Program, Sheba Medical Center, Tel Hashomer, Israel PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Ben Pode-Shakked, Metabolic Disease Unit, Edmond and Lily Safra Children's Hospital, Ramat Gan, Israel; ben_pode{at}hotmail.com
View Full Text

Citation

Bolkier Y, Barel O, Marek-Yagel D, et al
Whole-exome sequencing reveals a monogenic cause in 56% of individuals with laterality disorders and associated congenital heart defects
Journal of Medical Genetics 2022;59:691-696.

Publication history

  • Received February 9, 2021
  • Accepted June 19, 2021
  • First published July 2, 2021.
Online issue publication 
November 15, 2022

Article Versions

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Copyright information

© Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.