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Complex traits
Original research
Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants

Authors

  • Daniel N. Frank Department of Medicine, Division of Infectious Diseases, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Arnaud P. J. Giese Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Lena Hafren Department of Otorhinolaryngology, Head & Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland PubMed articlesGoogle scholar articles
  • Tori C. Bootpetch Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Talitha Karisse L. Yarza Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Newborn Hearing Screening Reference Center, University of the Philippines Manila - National Institutes of Health, Manila, Philippines PubMed articlesGoogle scholar articles
  • Matthew J. Steritz Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Melquiadesa Pedro Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines PubMed articlesGoogle scholar articles
  • Patrick John Labra Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines PubMed articlesGoogle scholar articles
  • Kathleen A. Daly Department of Otolaryngology, Head and Neck Surgery, University of Minnesota, Minneapolis, Minnesota, USA PubMed articlesGoogle scholar articles
  • Ma. Leah C. Tantoco Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Newborn Hearing Screening Reference Center, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Wasyl Szeremeta Department of Otolaryngology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA PubMed articlesGoogle scholar articles
  • Maria Rina T. Reyes-Quintos Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Newborn Hearing Screening Reference Center, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines National Institutes of Health, University of the Philippines Manila, Manila, Philippines PubMed articlesGoogle scholar articles
  • Niaz Ahankoob Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Erasmo Gonzalo d.V. Llanes Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Newborn Hearing Screening Reference Center, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Harold S. Pine Department of Otolaryngology, University of Texas Medical Branch at Galveston, Galveston, Texas, USA PubMed articlesGoogle scholar articles
  • Sairah Yousaf Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Diana Ir Department of Medicine, Division of Infectious Diseases, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Elisabet Einarsdottir Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland PubMed articlesGoogle scholar articles
  • Rhodieleen Anne R. de la Cruz Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Nanette R. Lee Department of Anthropology, Sociology and History, University of San Carlos, Cebu City, Philippines PubMed articlesGoogle scholar articles
  • Rachelle Marie A. Nonato Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Charles E. Robertson Department of Medicine, Division of Infectious Diseases, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  • Kimberly Mae C. Ong Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Jose Pedrito M. Magno Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Alessandra Nadine E. Chiong Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Ma. Carmina Espiritu-Chiong Renergy Dermatology & Laser Center, Taguig City, Philippines PubMed articlesGoogle scholar articles
  • Maria Luz San Agustin Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Teresa Luisa G. Cruz Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Generoso T. Abes Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Michael J. Bamshad Department of Genome Sciences, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Eva Maria Cutiongco-de la Paz National Institutes of Health, University of the Philippines Manila, Manila, Philippines Philippine Genome Center, University of the Philippines Diliman, Quezon City, Philippines PubMed articlesGoogle scholar articles
  • Juha Kere Folkhälsan Institute of Genetics, University of Helsinki, Helsinki, Finland Molecular Neurology Research Program, University of Helsinki, Helsinki, Finland Department of Medical and Molecular Genetics, King's College London, London, UK PubMed articlesGoogle scholar articles
  • Deborah A. Nickerson Department of Genome Sciences, University of Washington, Seattle, Washington, USA PubMed articlesGoogle scholar articles
  • Karen L. Mohlke Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA PubMed articlesGoogle scholar articles
  • Saima Riazuddin Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Abner Chan Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Petri S. Mattila Department of Otorhinolaryngology, Head & Neck Surgery, University of Helsinki and Helsinki University Hospital, Helsinki, Finland PubMed articlesGoogle scholar articles
  • Suzanne M. Leal Center for Statistical Genetics, Gertrude H. Sergievsky Center, Taub Institute for Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA PubMed articlesGoogle scholar articles
  • Allen F. Ryan Division of Otolaryngology, Department of Surgery, University of California San Diego School of Medicine and Veterans Affairs Medical Center, La Jolla, California, USA PubMed articlesGoogle scholar articles
  • Zubair M. Ahmed Department of Otorhinolaryngology, Head and Neck Surgery, University of Maryland, Baltimore, Maryland, USA PubMed articlesGoogle scholar articles
  • Tasnee Chonmaitree Division of Infectious Diseases, Department of Pediatrics, University of Texas Medical Branch at Galveston, Galveston, Texas, USA PubMed articlesGoogle scholar articles
  • Michele M. Sale Center for Public Health Genomics, School of Medicine, Department of Biochemistry and Molecular Genetics, and Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia, USA PubMed articlesGoogle scholar articles
  • Charlotte M. Chiong Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Newborn Hearing Screening Reference Center, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Department of Otorhinolaryngology, Philippine General Hospital, Manila, Philippines PubMed articlesGoogle scholar articles
  • Regie Lyn P. Santos-Cortez Department of Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA Philippine National Ear Institute, University of the Philippines Manila - National Institutes of Health, Manila, Philippines Center for Children's Surgery, Children's Hospital Colorado, Aurora, Colorado, USA PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Regie Lyn P. Santos-Cortez, Otolaryngology-Head and Neck Surgery, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA; regie.santos-cortez{at}cuanschutz.edu
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Citation

Frank DN, Giese APJ, Hafren L, et al
Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants
Journal of Medical Genetics 2021;58:442-452.

Publication history

  • Received January 7, 2020
  • Revised May 6, 2020
  • Accepted May 24, 2020
  • First published July 24, 2020.
Online issue publication 
January 10, 2022

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© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ.