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Variants of uncertain clinical significance in hereditary breast and ovarian cancer genes: best practices in functional analysis for clinical annotation

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  • Contributors This manuscript emerged from discussions held at a Netherlands Cancer Institute (NKI) workshop on Functional Analysis of Sequence Variants in Hereditary Breast and Ovarian Cancer Genes (Amsterdam, The Netherlands). AM and MV planned the study and coordinated the discussions and are responsible for the overall content as guarantors. All authors contributed to the discussions, to the preparation and editing of the manuscript, reviewed and approved the final manuscript.

  • Funding The meeting was supported by funds from the Cancer Genomics Center Netherlands through the Netherlands Organization for Scientific Research (NWO), the Royal Netherlands Academy of Arts and Sciences (KNAW), the Danish Counsil for Independent Research (DFF), the Netherlands Cancer Institute and from IDT and BIOKÉ.

  • Competing interests LW is an inventor and owner of a patent on a test system for determining genotoxicities and cancer risk.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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