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High-sensitivity microsatellite instability assessment for the detection of mismatch repair defects in normal tissue of biallelic germline mismatch repair mutation carriers

Authors

  • Maribel González-Acosta Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Fátima Marín Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Benjamin Puliafito Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Nuria Bonifaci Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Anna Fernández Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Matilde Navarro Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Hector Salvador Pediatric Oncology Unit, Hospital Sant Joan de Déu, Esplugues, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Francesc Balaguer Department of Gastroenterology, Hospital Clínic, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas (CIBERehd), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain PubMed articlesGoogle scholar articles
  • Silvia Iglesias Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Angela Velasco Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Institut d’Investigació Biomèdica de Girona - IDIBGI, Girona, Spain PubMed articlesGoogle scholar articles
  • Elia Grau Garces Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Victor Moreno Cancer Prevention and Control Program, Catalan Institute of Oncology - ICO, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, CIBERESP, L'Hospitalet de Llobregat, Barcelona, Spain Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Luis Ignacio Gonzalez-Granado Immunodeficiencies Unit, Department of Pediatrics, Doce de Octubre University Hospital, i+12 Research Institute; Complutense University of Madrid, Madrid, Spain PubMed articlesGoogle scholar articles
  • Pilar Guerra-García Hematology and Oncology Unit, Department of Pediatrics, Doce de Octubre University Hospital, Madrid, Spain PubMed articlesGoogle scholar articles
  • Rosa Ayala Department of Hematology, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain PubMed articlesGoogle scholar articles
  • Benoît Florkin University Department of Pediatrics, CHR Citadelle, Liege, Belgium PubMed articlesGoogle scholar articles
  • Christian Kratz Department of Pediatric Hematology and Oncology, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Tim Ripperger Department of Human Genetics, Hannover Medical School, Hannover, Germany PubMed articlesGoogle scholar articles
  • Thorsten Rosenbaum Department of Pediatrics, Sana Kliniken Duisburg, Duisburg, Germany PubMed articlesGoogle scholar articles
  • Danuta Januszkiewicz-Lewandowska Department of Pediatric Oncology, Hematology and Transplantation, Poznań University of Medical Sciences, Poznań, Poland PubMed articlesGoogle scholar articles
  • Amedeo A Azizi Department of Pediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria PubMed articlesGoogle scholar articles
  • Iman Ragab Pediatrics Department, Hematology-Oncology Unit, Faculty of Medicine, Ain Shams University, Cairo, Egypt PubMed articlesGoogle scholar articles
  • Michaela Nathrath Pediatric Hematology and Oncology, Klinikum Kassel, Kassel, Germany Pediatric Oncology Center, Department of Pediatrics, Technische Universität München, Munchen, Germany PubMed articlesGoogle scholar articles
  • Hans-Jürgen Pander Institut für Klinische Genetik, Olgahospital, Stuttgart, Germany PubMed articlesGoogle scholar articles
  • Stephan Lobitz Department of Pediatric Oncology/Pediatric Hematology, Kliniken der Stadt Köln gGmbH, Children’s Hospital Amsterdamer Strasse, Koln, Germany PubMed articlesGoogle scholar articles
  • Manon Suerink Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Karin Dahan Centre de Génétique Humaine, Institut de Pathologie et de Génétique (IPG), Gosselies, Belgium PubMed articlesGoogle scholar articles
  • Thomas Imschweiler Pediatric Oncology, Helios-Klinikum, Krefeld, Germany PubMed articlesGoogle scholar articles
  • Ugur Demirsoy Department of Pediatric Oncology, Kocaeli Universitesi, Kocaeli, Turkey PubMed articlesGoogle scholar articles
  • Joan Brunet Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Institut d’Investigació Biomèdica de Girona - IDIBGI, Girona, Spain PubMed articlesGoogle scholar articles
  • Conxi Lázaro Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Daniel Rueda Hereditary Cancer Laboratory, Doce de Octubre University Hospital, i+12 Research Institute, Madrid, Spain PubMed articlesGoogle scholar articles
  • Katharina Wimmer Division of Human Genetics, Medical University Innsbruck, Innsbruck, Austria PubMed articlesGoogle scholar articles
  • Gabriel Capellá Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  • Marta Pineda Hereditary Cancer Program, Catalan Institute of Oncology - ICO, Hereditary Cancer Group, Molecular Mechanisms and Experimental Therapy in Oncology Program, Institut d’Investigació Biomèdica de Bellvitge – IDIBELL, Ciber Oncología (CIBERONC) - Instituto de Salud Carlos III, L'Hospitalet de Llobregat, Barcelona, Spain PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Gabriel Capellá, Hereditary Cancer Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat 08908, Catalunya, Spain; gcapella{at}iconcologia.net; Dr Marta Pineda, Hereditary Cancer Program, Catalan Institute of Oncology, L'Hospitalet de Llobregat 08908, Catalunya, Spain; mpineda{at}iconcologia.net
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Citation

González-Acosta M, Marín F, Puliafito B, et al
High-sensitivity microsatellite instability assessment for the detection of mismatch repair defects in normal tissue of biallelic germline mismatch repair mutation carriers

Publication history

  • Received May 7, 2019
  • Revised July 16, 2019
  • Accepted July 16, 2019
  • First published September 7, 2019.
Online issue publication 
March 24, 2020

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