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Genetic T-type calcium channelopathies
  1. Norbert Weiss1,
  2. Gerald W Zamponi2
  1. 1 Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Praha, Czech Republic
  2. 2 Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada
  1. Correspondence to Dr Norbert Weiss, Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Praha 166 10, Czech Republic; weiss{at}; Dr Gerald W Zamponi, Department of Physiology and PharmacologyCumming School of Medicine, University of Calgary, Calgary T2N 4N1, Alberta, Canada; zamponi{at}


T-type channels are low-voltage-activated calcium channels that contribute to a variety of cellular and physiological functions, including neuronal excitability, hormone and neurotransmitter release as well as developmental aspects. Several human conditions including epilepsy, autism spectrum disorders, schizophrenia, motor neuron disorders and aldosteronism have been traced to variations in genes encoding T-type channels. In this short review, we present the genetics of T-type channels with an emphasis on structure-function relationships and associated channelopathies.

  • calcium channels
  • t-type channels
  • cav3 channels
  • mutation
  • channelopathies
  • epilepsy
  • autism spectrum disorders
  • schizophrenia
  • amyotrophic lateral sclerosis
  • aldosteronism

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  • Contributors NW and GWZ analysed the literature and wrote the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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