Addition of a 161-SNP polygenic risk score to family history-based risk prediction: impact on clinical management in non-BRCA1/2 breast cancer families

Inge M M Lakeman; Florentine S Hilbers; Mar Rodríguez-Girondo; Andrew Lee; Maaike P G Vreeswijk; Antoinette Hollestelle; Caroline Seynaeve; Hanne Meijers-Heijboer; Jan C Oosterwijk; Nicoline Hoogerbrugge; Edith Olah; Hans F A Vasen; Christi J van Asperen; Peter Devilee

doi:10.1136/jmedgenet-2019-106072

Article info

Cancer genetics

Original article

Addition of a 161-SNP polygenic risk score to family history-based risk prediction: impact on clinical management in non-BRCA1/2 breast cancer families

Authors

Inge M M Lakeman Department of Human Genetics, Leids Universitair Medisch Centrum, Leiden, The Netherlands PubMed articles Google scholar articles
Florentine S Hilbers Department of Human Genetics, Leids Universitair Medisch Centrum, Leiden, The Netherlands Breast International Group (BIG), Brussels, Belgium PubMed articles Google scholar articles
Mar Rodríguez-Girondo Department of Medical Statistics and Bioinformatics, Leids Universitair Medisch Centrum, Leiden, The Netherlands PubMed articles Google scholar articles
Andrew Lee Public Health and Primary Care, Centre for Cancer Gentic Epidemiology, Cambridge University, Cambridge, UK PubMed articles Google scholar articles
Maaike P G Vreeswijk Department of Human Genetics, Leids Universitair Medisch Centrum, Leiden, The Netherlands PubMed articles Google scholar articles
Antoinette Hollestelle Department of Medical Oncology, Erasmus MC Kanker Instituut, Rotterdam, The Netherlands PubMed articles Google scholar articles
Caroline Seynaeve Department of Medical Oncology, Erasmus MC Kanker Instituut, Rotterdam, The Netherlands PubMed articles Google scholar articles
Hanne Meijers-Heijboer Department of Clinical Genetics, VU medisch centrum, Amsterdam, The Netherlands PubMed articles Google scholar articles
Jan C Oosterwijk Department of Genetics, Universitair Medisch Centrum Groningen, Groningen, The Netherlands PubMed articles Google scholar articles
Nicoline Hoogerbrugge Department of Human Genetics, Universitair Medisch Centrum Sint Radboud, Nijmegen, The Netherlands PubMed articles Google scholar articles
Edith Olah Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary PubMed articles Google scholar articles
Hans F A Vasen Department of Gastroenterology and Hepatology, Leids Universitair Medisch Centrum, Leiden, The Netherlands PubMed articles Google scholar articles
Christi J van Asperen Department of Clinical Genetics, Leids Universitair Medisch Centrum, Leiden, The Netherlands PubMed articles Google scholar articles
Peter Devilee Department of Human Genetics, Leids Universitair Medisch Centrum, Leiden, The Netherlands Department of Pathology, Leids Universitair Medisch Centrum, Leiden, The Netherlands PubMed articles Google scholar articles

Correspondence to Dr Peter Devilee, Human Genetics, Leids Universitair Medisch Centrum, Leiden 2333ZA, Netherlands; p.devilee{at}lumc.nl

View Full Text

Citation

Lakeman IMM, Hilbers FS, Rodríguez-Girondo M, et al

Addition of a 161-SNP polygenic risk score to family history-based risk prediction: impact on clinical management in non-BRCA1/2 breast cancer families

Journal of Medical Genetics 2019;56:581-589.

Publication history

Received February 8, 2019
Revised March 29, 2019
Accepted April 20, 2019
First published June 11, 2019.

Online issue publication

August 21, 2019

Article Versions

Previous version (21 August 2019).
You are viewing the most recent version of this article.

Request permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Main menu

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Log in using your username and password

Main menu

Log in using your username and password

You are here

Authors

Citation

Publication history

Article Versions

Request permissions

Copyright information

Read the full text or download the PDF:

Log in using your username and password