Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883)

Jan Hauke; Eric Hahnen; Stephanie Schneider; Alexander Reuss; Lisa Richters; Stefan Kommoss; André Heimbach; Frederik Marmé; Sandra Schmidt; Katharina Prieske; Heidrun Gevensleben; Alexander Burges; Julika Borde; Nikolaus De Gregorio; Peter Nürnberg; Ahmed El-Balat; Holger Thiele; Felix Hilpert; Janine Altmüller; Werner Meier; Dimo Dietrich; Rainer Kimmig; Birgid Schoemig-Markiefka; Karin Kast; Elena Braicu; Klaus Baumann; Christian Jackisch; Tjoung-Won Park-Simon; Corinna Ernst; Lars Hanker; Jacobus Pfisterer; Andreas Schnelzer; Andreas du Bois; Rita K Schmutzler; Philipp Harter

doi:10.1136/jmedgenet-2018-105930

Article info

Cancer genetics

Original article

Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883)

Authors

Jan Hauke Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Eric Hahnen Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Stephanie Schneider Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte Evangelische Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany PubMed articles Google scholar articles
Alexander Reuss Coordinating Center for Clinical Trials, Philipps-University of Marburg, Marburg, Germany PubMed articles Google scholar articles
Lisa Richters Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Stefan Kommoss Department of Women's Health, University Hospital Tuebingen, Tuebingen, Germany PubMed articles Google scholar articles
André Heimbach Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Frederik Marmé National Center for Tumor Disease, Department of Gynecology, University of Heidelberg, Heidelberg, Germany PubMed articles Google scholar articles
Sandra Schmidt Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Katharina Prieske Department of Gynecology and Gynecologic Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Heidrun Gevensleben Institute of Pathology, University Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Alexander Burges Department of Gynecology, University Hospital Munich-Großhadern, Munich, Germany PubMed articles Google scholar articles
Julika Borde Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Nikolaus De Gregorio Department of Gynecology and Obstetrics, University Hospital, Universität Ulm, Ulm, Germany PubMed articles Google scholar articles
Peter Nürnberg Cologne Center for Genomics (CCG) & Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany PubMed articles Google scholar articles
Ahmed El-Balat Department of Gynecology, University of Frankfurt, Frankfurt, Germany PubMed articles Google scholar articles
Holger Thiele Cologne Center for Genomics (CCG) & Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Felix Hilpert Department of Gynecology, University of Kiel, Kiel, Germany Onkologisches Therapiezentrum, Krankenhaus Jerusalem, Hamburg, Germany PubMed articles Google scholar articles
Janine Altmüller Cologne Center for Genomics (CCG) & Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany Center for Molecular Medicine Cologne (CMMC), University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Werner Meier Department of Gynecology and Obstetrics, University Hospital Duesseldorf, Duesseldorf, Germany PubMed articles Google scholar articles
Dimo Dietrich Department of Otolaryngology, Head and Neck Surgery, University Hospital Bonn, Bonn, Germany PubMed articles Google scholar articles
Rainer Kimmig Department of Gynecology, University of Essen, Essen, Germany PubMed articles Google scholar articles
Birgid Schoemig-Markiefka Institute of Pathology, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Karin Kast Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany German Cancer Consortium (DKTK), Dresden and German Cancer Research Center (DKFZ), National Center for Tumor Diseases (NCT), Partner Site Dresden, Heidelberg, Germany PubMed articles Google scholar articles
Elena Braicu Department of Gynecology and Gynecological Oncology, Charité, Berlin, Germany PubMed articles Google scholar articles
Klaus Baumann Department of Gynecology, Gynecologic Endocrinology and Oncology, University of Gießen and Marburg GmbH, Marburg, Germany Department of Gynecology and Obstetrics, Klinikum Ludwigshafen, Ludwigshafen, Germany PubMed articles Google scholar articles
Christian Jackisch Department of Gynecology and Obstetrics, Sana Klinikum, Offenbach, Germany PubMed articles Google scholar articles
Tjoung-Won Park-Simon Department of Gynecology, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Corinna Ernst Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Lars Hanker Department of Gynecology & Obstetrics, University Hospital Schleswig-Holstein, Campus Lübeck, Lübeck, Germany PubMed articles Google scholar articles
Jacobus Pfisterer Gynecologic Oncology Center, Kiel, Germany PubMed articles Google scholar articles
Andreas Schnelzer Department of Obstetrics and Gynecology, Klinikum rechts der Isar, Technical University Munich, Munich, Germany Department of Obstetrics and Gynecology, RoMed Klinikum Rosenheim, Rosenheim, Germany PubMed articles Google scholar articles
Andreas du Bois Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte Evangelische Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany PubMed articles Google scholar articles
Rita K Schmutzler Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Philipp Harter Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte Evangelische Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany PubMed articles Google scholar articles

Correspondence to Dr Eric Hahnen, Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO), Medical Faculty, University Hospital Cologne, Cologne 50931, Germany; eric.hahnen{at}uk-koeln.de

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Citation

Hauke J, Hahnen E, Schneider S, et al

Deleterious somatic variants in 473 consecutive individuals with ovarian cancer: results of the observational AGO-TR1 study (NCT02222883)

Journal of Medical Genetics 2019;56:574-580.

Publication history

Received December 7, 2018
Revised February 26, 2019
Accepted March 14, 2019
First published April 12, 2019.

Online issue publication

August 21, 2019

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