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Natural history of renal tumours in von Hippel-Lindau disease: a large retrospective study of Chinese patients
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  • Published on:
    Renal tumours in neonates are often misdiagnosed -A major concern.
    • Prof.Dr.Jogenananda Pramanik, Professor & Dean Careers Abroad Institute School of Medicine, Jamaica,WI
    • Other Contributors:
      • Dr. Evertz Solomon, Associate Professor
      • Dr.Orette Williams, Associate Professor
      • Dr Azzard Comrie, Associate Professor
      • Prof.Dr.Tanu Pramanik, Principal & Professor

    We read with interest the extensive retrospective study on von Hippel-Lindau disease as described by the authors (1) . This original article enlightened us about the age of onset, initial tumour size, concomitant tumours, mutation type and mutation location had an effect on growth rate in VHL-related RCC.It was very interesting to note that these renal tumours larger than 4 cm grew faster than those smaller than 4 cm.
    Abdominal masses are frequent in newborn infants, two thirds being renal in origin and occasionally, a renal mass may be malignant and correspond to congenital mesoblastic nephroma, Wilms’ tumor, or fetal hamartoma(2).Birt-Hogg-Dubé (BHD) syndrome is another autosomal dominant genodermatosis characterized by increased risk of renal neoplasia and spontaneous pneumothorax (3) This syndrome is linked to mutations in the FLCN gene, which encodes folliculin and is preferentially expressed in the skin, kidney, and lung (4).In addition,renal epithelial and stromal tumors (REST) is a new concept gathering two benign mixed mesenchymal and epithelial tumors: cystic nephroma and mixed epithelial and stromal tumors [MEST] (5).Since 1998 new entities have surfaced in renal tumor classification and have been included in the WHO 2004 classification e.g new elements in the Bellini carcinoma definition.(6). Renal tumours of genetic origin may often confer diagnostic challenges. Whatever the nature of the renal mass, early intervention may save the kidney or the patient...

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    Conflict of Interest:
    None declared.