Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning

Jian Huang; Zhaoyang Qian; Yuhua Gong; Yanzhou Wang; Yanfang Guan; Yingxin Han; Xin Yi; Wanqiu Huang; Liyan Ji; Jiajia Xu; Mengyuan Su; Qing Yuan; Shujian Cui; Jinling Zhang; Chaohui Bao; Weilong Liu; Xi Chen; Ming Zhang; Xiaohuan Gao; Renhua Wu; Yinxin Zhang; Huicheng Xu; Shida Zhu; Hongmei Zhu; Ling Yang; Xun Xu; Pingyu Zhou; Zhiqing Liang

doi:10.1136/jmedgenet-2018-105745

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Cancer genetics

Original article

Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning

Authors

Jian Huang Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome at Shanghai, Shanghai, China PubMed articles Google scholar articles
Zhaoyang Qian Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Yuhua Gong Geneplus-Beijing, Beijing, China PubMed articles Google scholar articles
Yanzhou Wang Department of Obstetrics and Gynecology, Southwestern Hospital, Third Military Medical University, Chongqing, China PubMed articles Google scholar articles
Yanfang Guan Geneplus-Beijing, Beijing, China PubMed articles Google scholar articles
Yingxin Han Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Xin Yi Geneplus-Beijing, Beijing, China PubMed articles Google scholar articles
Wanqiu Huang Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Liyan Ji Geneplus-Beijing, Beijing, China PubMed articles Google scholar articles
Jiajia Xu Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Mengyuan Su Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Qing Yuan Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Shujian Cui Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome at Shanghai, Shanghai, China PubMed articles Google scholar articles
Jinling Zhang Shenzhen People’s Hospital, Second Clinical Medical College of Jinan University, Shenzhen, China PubMed articles Google scholar articles
Chaohui Bao Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Weilong Liu Shenzhen Key Laboratory of Infection and Immunity, Shenzhen Third People’s Hospital, Guangdong Medical University, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Xi Chen Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Ming Zhang Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Xiaohuan Gao Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Renhua Wu Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Yinxin Zhang Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China PubMed articles Google scholar articles
Huicheng Xu Department of Obstetrics and Gynecology, Southwestern Hospital, Third Military Medical University, Chongqing, China PubMed articles Google scholar articles
Shida Zhu BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Hongmei Zhu Binhai Genomics Institute, BGI-Tianjin, Tianjin, China BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Ling Yang Geneplus-Beijing, Beijing, China PubMed articles Google scholar articles
Xun Xu BGI-Shenzhen, Shenzhen, Guangdong, China PubMed articles Google scholar articles
Pingyu Zhou STD Institute, Shanghai Skin Disease Hospital, Tong Ji University, Shanghai, China PubMed articles Google scholar articles
Zhiqing Liang Department of Obstetrics and Gynecology, Southwestern Hospital, Third Military Medical University, Chongqing, China PubMed articles Google scholar articles

Correspondence to Dr Jian Huang, Shanghai Jiao Tong University, Shanghai 200240, China; jianhuang{at}sjtu.edu.cn, Dr Pingyu Zhou, STD Institute, Shanghai Skin Disease Hospital, Tong Ji University, Shanghai 200050, China; zpyls{at}yahoo.com and Dr Zhiqing Liang, Department of Obstetrics & Gynecology, Southwestern Hospital, Third Military Medical University, Chongqing 400038, China; zhi.lzliang{at}gmail.com

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Citation

Huang J, Qian Z, Gong Y, et al

Comprehensive genomic variation profiling of cervical intraepithelial neoplasia and cervical cancer identifies potential targets for cervical cancer early warning

Journal of Medical Genetics 2019;56:186-194.

Publication history

Received September 12, 2018
Revised November 13, 2018
Accepted November 16, 2018
First published December 19, 2018.

Online issue publication

February 22, 2019

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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