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Original article
Upregulated immune checkpoint HHLA2 in clear cell renal cell carcinoma: a novel prognostic biomarker and potential therapeutic target
  1. Dongming Chen1,
  2. Wei Chen2,
  3. Yong Xu3,
  4. Meng Zhu1,
  5. Yi Xiao1,
  6. Yanhao Shen1,
  7. Shuai Zhu1,
  8. Changchun Cao1,
  9. Xianlin Xu1
  1. 1 Department of Urology, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing, China
  2. 2 Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
  3. 3 Department of Nephrology, Huai’an Second People’s Hospital and the Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China
  1. Correspondence to Changchun Cao, Department of Urology The Affiliated Sir Run Run Hospital of Nanjing Medical University Nanjing China ; caochangchun0424{at}126.com and Dr Xianlin Xu, Department of Urology, The Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing 211166, China; xianlinxu{at}njmu.edu.cn

Footnotes

  • DC, WC and YX contributed equally.

  • Contributors XX and CC contributed to the conception and design of the study. XX, WC, YX, CC and DC contributed to the provision of study materials or patients and manuscript revision. DC, MZ and YZ were responsible for the collection and assembly of data. MZ, SZ and YS were responsible for the data analysis and interpretation. DC, XX and CC wrote the manuscript. All authors approved the final manuscript.

  • Funding This work was supported by the Natural Science Foundation of Jiangsu Province (Grant no. BK20141161).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Approved by the Affiliated Sir Run Run Hospital of Nanjing Medical University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it was published Online First. A statement of equal contribution has been added.

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Footnotes

  • DC, WC and YX contributed equally.

  • Contributors XX and CC contributed to the conception and design of the study. XX, WC, YX, CC and DC contributed to the provision of study materials or patients and manuscript revision. DC, MZ and YZ were responsible for the collection and assembly of data. MZ, SZ and YS were responsible for the data analysis and interpretation. DC, XX and CC wrote the manuscript. All authors approved the final manuscript.

  • Funding This work was supported by the Natural Science Foundation of Jiangsu Province (Grant no. BK20141161).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Approved by the Affiliated Sir Run Run Hospital of Nanjing Medical University.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Correction notice This article has been corrected since it was published Online First. A statement of equal contribution has been added.

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