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Original article
XRCC2 mutation causes meiotic arrest, azoospermia and infertility
  1. Yongjia Yang1,2,
  2. Jihong Guo1,2,3,
  3. Lei Dai1,2,3,
  4. Yimin Zhu1,4,
  5. Hao Hu1,5,
  6. Lihong Tan1,
  7. Weijian Chen1,
  8. Desheng Liang1,2,
  9. Jingliang He1,2,
  10. Ming Tu1,
  11. Kewei Wang1,
  12. Lingqian Wu1,2
  1. 1 The Laboratory of Genetics and Metabolism, Hunan Children’s Research Institute (HCRI), Hunan Children’s Hospital, University of South China, Changsha, China
  2. 2 State Key Laboratory of Medical Genetics, Central South University, Changsha, China
  3. 3 Xiangya Hospital, Central South University, Changsha, China
  4. 4 Hunan People’s Hospital, Hunan Normal University, Changsha, China
  5. 5 Department of Genetics, Maternal and Child Health Hospital of Hunan Province, Changsha, China
  1. Correspondence to Dr Yongjia Yang, Laboratory of Genetics and Metabolism, HunanChildren’s Research Institute (HCRI), Hunan Children’s Hospital, University of South China, Changsha, Hunan 410007, China; yongjia727{at}aliyun.com and Dr Lingqian Wu, State Key Laboratory of Medical Genetics Central South University Changsha China; wulingqian{at}sklmg.edu.cn

Footnotes

  • YY and JG contributed equally.

  • Contributors YJY and LQW designed the research. YJY, JHG, LD, YMZ, HH, LHT, WJC, JHG, MT, KWW performed the sample collection and the research. YJY, JHG and LD performed the bioinformatics analysis. YJY and LQW analysed the experimental data and wrote the paper.

  • Funding This work was supported by grants from the National Natural Science Foundation of China (31501017, to YJY), the Key Nature Science Foundation of Hunan Children’s Hospital (2015-0002, to YJY), the National Natural Science Foundation of China (81771599, to LQW), and the Key Laboratory fund of Hunan Province (2018TP1028, to YYJ).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Hunan Children’s Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • YY and JG contributed equally.

  • Contributors YJY and LQW designed the research. YJY, JHG, LD, YMZ, HH, LHT, WJC, JHG, MT, KWW performed the sample collection and the research. YJY, JHG and LD performed the bioinformatics analysis. YJY and LQW analysed the experimental data and wrote the paper.

  • Funding This work was supported by grants from the National Natural Science Foundation of China (31501017, to YJY), the Key Nature Science Foundation of Hunan Children’s Hospital (2015-0002, to YJY), the National Natural Science Foundation of China (81771599, to LQW), and the Key Laboratory fund of Hunan Province (2018TP1028, to YYJ).

  • Competing interests None declared.

  • Patient consent Obtained.

  • Ethics approval Hunan Children’s Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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