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  • Penetrance estimates for BRCA1, BRCA2 (also applied to Lynch syndrome) based on presymptomatic testing: a new unbiased method to assess risk?

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Cancer genetics
Original article
Penetrance estimates for BRCA1, BRCA2 (also applied to Lynch syndrome) based on presymptomatic testing: a new unbiased method to assess risk?

Authors

  • D Gareth Evans Division of Evolution and Genomic Science, Manchester Centre for Genomic Medicine, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  • Emma Woodward Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  • Elaine F Harkness Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK Division of Informatics, Imaging and Data Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, University of Manchester, Manchester, UK PubMed articlesGoogle scholar articles
  • Anthony Howell Prevent Breast Cancer Centre, Wythenshawe Hospital, Manchester University NHS Foundation Trust, Manchester, UK Department of Medical Oncology, Christie Hospital, Manchester, UK PubMed articlesGoogle scholar articles
  • Inga Plaskocinska Department of Medical Genetics, Cancer Research UK Cambridge Centre, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Eamonn R Maher Department of Medical Genetics, Cancer Research UK Cambridge Centre, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Marc D Tischkowitz Department of Medical Genetics, Cancer Research UK Cambridge Centre, NIHR Cambridge Biomedical Research Centre, University of Cambridge, Cambridge, UK PubMed articlesGoogle scholar articles
  • Fiona Lalloo Manchester Centre for Genomic Medicine, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester, UK PubMed articlesGoogle scholar articles
  1. Correspondence to Professor D Gareth Evans, Manchester Centre for Genomic Medicine, St. Mary’s Hospital, Manchester M13 9WL, UK; gareth.evans{at}mft.nhs.uk
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Citation

Evans DG, Woodward E, Harkness EF, et al
Penetrance estimates for BRCA1, BRCA2 (also applied to Lynch syndrome) based on presymptomatic testing: a new unbiased method to assess risk?
Journal of Medical Genetics 2018;55:442-448.

Publication history

  • Received December 17, 2017
  • Revised January 29, 2018
  • Accepted February 11, 2018
  • First published February 26, 2018.
Online issue publication 
June 25, 2018

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© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.