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Original article
No correlation between mtDNA amount and methylation levels at the CpG island of POLG exon 2 in wild-type and mutant human differentiated cells
  1. Julie Steffann1,
  2. Aurore Pouliet1,
  3. Houda Adjal1,
  4. Christine Bole1,
  5. Cécile Fourrage1,
  6. Jelena Martinovic2,
  7. Louise Rolland-Galmiche1,
  8. Agnes Rotig1,
  9. Frédéric Tores1,
  10. Arnold Munnich1,
  11. Jean-Paul Bonnefont1
  1. 1Imagine Institute UMR1163, and Paris Descartes University, Hôpital Necker-Enfants Malades, Paris Cedex, France
  2. 2Fœtopathologie, Hôpital Antoine-Béclère, Clamart, France
  1. Correspondence to Professor Julie Steffann, Imagine Institute UMR1163, and Paris Descartes University, Hôpital Necker-Enfants Malades, 149 rue de Sèvres, 75743 Paris Cedex 15, France; julie.steffann{at}inserm.fr

Footnotes

  • Contributors JS and J-PB planned and supervised the study. AP and HA performed the experiments. CB, LR-G, JM and AR contributed to reagents, materials and analysis tools. Bioinformatic data analysis was performed by CF and FT. JS and J-PB analysed the data. JS, JP-B and AM wrote the manuscript.

  • Funding This work was supported by “Agence de la Biomedecine”.

  • Competing interests None declared.

  • Ethics approval Agence de la Biomedecine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Contributors JS and J-PB planned and supervised the study. AP and HA performed the experiments. CB, LR-G, JM and AR contributed to reagents, materials and analysis tools. Bioinformatic data analysis was performed by CF and FT. JS and J-PB analysed the data. JS, JP-B and AM wrote the manuscript.

  • Funding This work was supported by “Agence de la Biomedecine”.

  • Competing interests None declared.

  • Ethics approval Agence de la Biomedecine.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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