Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

Karin Kast; Kerstin Rhiem; Barbara Wappenschmidt; Eric Hahnen; Jan Hauke; Britta Bluemcke; Verena Zarghooni; Natalie Herold; Nina Ditsch; Marion Kiechle; Michael Braun; Christine Fischer; Nicola Dikow; Sarah Schott; Nils Rahner; Dieter Niederacher; Tanja Fehm; Andrea Gehrig; Clemens Mueller-Reible; Norbert Arnold; Nicolai Maass; Guntram Borck; Nikolaus de Gregorio; Caroline Scholz; Bernd Auber; Raymonda Varon-Manteeva; Dorothee Speiser; Judit Horvath; Nadine Lichey; Pauline Wimberger; Sylvia Stark; Ulrike Faust; Bernhard H F Weber; Gunter Emons; Silke Zachariae; Alfons Meindl; Rita K Schmutzler; Christoph Engel

doi:10.1136/jmedgenet-2015-103672

Article info

Cancer genetics

Original article

Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

Authors

Karin Kast Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Kerstin Rhiem Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Barbara Wappenschmidt Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Eric Hahnen Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Jan Hauke Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Britta Bluemcke Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Verena Zarghooni Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Natalie Herold Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Nina Ditsch Department for Gynecology and Obstetrics, LMU Munich, Munich, Germany PubMed articles Google scholar articles
Marion Kiechle Department for Gynecology and Obstetrics, Technical University of Munich, Munich, Germany PubMed articles Google scholar articles
Michael Braun Breast Center, Department of Gynecology, Red Cross Hospital, Munich, Germany PubMed articles Google scholar articles
Christine Fischer Institute of Human Genetics, Heidelberg University, Heidelberg, Germany PubMed articles Google scholar articles
Nicola Dikow Institute of Human Genetics, Heidelberg University, Heidelberg, Germany PubMed articles Google scholar articles
Sarah Schott Department of Gynecology and Obstetrics, Heidelberg University Hospital, Heidelberg, Germany German Cancer Consortium (DKTK), NCT Heidelberg and German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Nils Rahner Medical Faculty, Institute of Human Genetics and Anthropology, Heinrich-Heine University, Düsseldorf, Germany PubMed articles Google scholar articles
Dieter Niederacher Department of Gynecology and Obstetrics, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany PubMed articles Google scholar articles
Tanja Fehm Department of Gynecology and Obstetrics, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany PubMed articles Google scholar articles
Andrea Gehrig Department of Human Genetics, University of Wuerzburg, Würzburg, Germany PubMed articles Google scholar articles
Clemens Mueller-Reible Department of Human Genetics, University of Wuerzburg, Würzburg, Germany PubMed articles Google scholar articles
Norbert Arnold Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany PubMed articles Google scholar articles
Nicolai Maass Department of Gynaecology and Obstetrics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts University Kiel, Kiel, Germany PubMed articles Google scholar articles
Guntram Borck Institute of Human Genetics, University of Ulm, Ulm, Germany PubMed articles Google scholar articles
Nikolaus de Gregorio Department of Gynecology and Obstetrics, University Hospital, Universität Ulm, Ulm, Germany PubMed articles Google scholar articles
Caroline Scholz Institute of Human Genetics, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Bernd Auber Institute of Human Genetics, Hannover Medical School, Hannover, Germany PubMed articles Google scholar articles
Raymonda Varon-Manteeva Institute of Medical and Human Genetics, Charite-University Medical Center, Berlin, Germany PubMed articles Google scholar articles
Dorothee Speiser Department of Gynecology, Charité University Medicine Berlin, Berlin, Germany PubMed articles Google scholar articles
Judit Horvath Institute for Human Genetics, University of Muenster, Münster, Germany PubMed articles Google scholar articles
Nadine Lichey Institute for Human Genetics, University of Muenster, Münster, Germany PubMed articles Google scholar articles
Pauline Wimberger Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, TU Dresden, Dresden, Germany German Cancer Consortium (DKTK) Dresden and German Cancer Research Center (DKFZ), Heidelberg, Germany PubMed articles Google scholar articles
Sylvia Stark Department of Gynecology and Obstetrics, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Ulrike Faust Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Tübingen, Germany PubMed articles Google scholar articles
Bernhard H F Weber Institute of Human Genetics, University of Regensburg, Regensburg, Germany PubMed articles Google scholar articles
Gunter Emons Department of Obstetrics and Gynecology, University of Göttingen, Göttingen, Germany PubMed articles Google scholar articles
Silke Zachariae Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles
Alfons Meindl Department for Gynecology and Obstetrics, Technical University of Munich, Munich, Germany PubMed articles Google scholar articles
Rita K Schmutzler Center for Hereditary Breast and Ovarian Cancer, Center for Integrated Oncology (CIO) and Center for Molecular Medicine Cologne (CMMC), Medical Faculty, University of Cologne and University Hospital Cologne, Cologne, Germany PubMed articles Google scholar articles
Christoph Engel Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany PubMed articles Google scholar articles

Correspondence to Karin Kast, Department of Gynecology and Obstetrics, University Hospital Carl Gustav Carus, TU Dresden, Fetscherstraße 74, Dresden 01069, Germany; karin.kast{at}uniklinikum-dresden.de

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Citation

Kast K, Rhiem K, Wappenschmidt B on behalf of the German Consortium for Hereditary Breast and Ovarian Cancer (GC-HBOC), et al

Prevalence of BRCA1/2 germline mutations in 21 401 families with breast and ovarian cancer

Journal of Medical Genetics 2016;53:465-471.

Publication history

Received November 28, 2015
Revised January 21, 2016
Accepted February 2, 2016
First published February 29, 2016.

Online issue publication

June 23, 2016

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