Multigene testing of moderate-risk genes: be mindful of the missense

E L Young; B J Feng; A W Stark; F Damiola; G Durand; N Forey; T C Francy; A Gammon; W K Kohlmann; K A Kaphingst; S McKay-Chopin; T Nguyen-Dumont; J Oliver; A M Paquette; M Pertesi; N Robinot; J S Rosenthal; M Vallee; C Voegele; J L Hopper; M C Southey; I L Andrulis; E M John; M Hashibe; J Gertz; Breast Cancer Family Registry; F Le Calvez-Kelm; F Lesueur; D E Goldgar; S V Tavtigian

doi:10.1136/jmedgenet-2015-103398

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Cancer genetics

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Multigene testing of moderate-risk genes: be mindful of the missense

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E L Young Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
B J Feng Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
A W Stark Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
F Damiola Breast Cancer Genetics Group, Cancer Research Centre of Lyon, Centre Léon Bérard, Lyon, France PubMed articles Google scholar articles
G Durand Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
N Forey Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
T C Francy Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
A Gammon Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
W K Kohlmann Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
K A Kaphingst Department of Communication and Huntsman Cancer Institute, University of Utah PubMed articles Google scholar articles
S McKay-Chopin Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
T Nguyen-Dumont Genetic Epidemiology Laboratory, The University of Melbourne, Melbourne, Victoria, Australia PubMed articles Google scholar articles
J Oliver Instituto de Ciencias Básicas y Medicina Experimental del Hospital Italiano de Buenos Aires, Buenos Aires, Argentina PubMed articles Google scholar articles
A M Paquette Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
M Pertesi Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
N Robinot Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
J S Rosenthal Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
M Vallee Cancer Genomics Laboratory, CHUQ Research Center, Quebec City, Canada PubMed articles Google scholar articles
C Voegele Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
J L Hopper Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia Department of Epidemiology (Genome Epidemiology Lab), Seoul National University School of Public Health, Seoul, Korea PubMed articles Google scholar articles
M C Southey Department of Communication and Huntsman Cancer Institute, University of Utah PubMed articles Google scholar articles
I L Andrulis Department of Molecular Genetics, Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, University of Toronto, Toronto, Ontario, Canada PubMed articles Google scholar articles
E M John Cancer Prevention Institute of California, Fremont, California, USA Department of Health Research and Policy, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, California, USA PubMed articles Google scholar articles
M Hashibe Department of Family and Preventive Medicine, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
J Gertz Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
Cancer Prevention Institute of California, Fremont, California, USA Google scholar articles
F Le Calvez-Kelm Genetic Cancer Susceptibility group, International Agency for Research on Cancer, Lyon, France PubMed articles Google scholar articles
F Lesueur Genetic Epidemiology of Cancer Team, Inserm, U900, Institut Curie, Paris, France PubMed articles Google scholar articles
D E Goldgar Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles
S V Tavtigian Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, USA PubMed articles Google scholar articles

Correspondence to Professor Sean V Tavtigian, Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah 84112, USA; sean.tavtigian{at}hci.utah.edu

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Citation

Young EL, Feng BJ, Stark AW, et al

Multigene testing of moderate-risk genes: be mindful of the missense

Journal of Medical Genetics 2016;53:366-376.

Publication history

Received July 17, 2015
Revised December 17, 2015
Accepted December 18, 2015
First published January 19, 2016.

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May 24, 2016

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