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Biomedical research post sequencing of the first human genome is increasingly eroding a traditional ecology of individualist science. It is, furthermore, normalising collective innovation and shared scientific discovery.1 ,2 Achieving sound statistical power in a genome-wide association study, for example, can often be well beyond the scope of any one researcher's capacity. For this reason and others, the scientific imperative of research collaboration can be more pronounced in the ‘omics’ disciplines,3 where millions of data points are needed to make global inferences about links between the human genome and disease.4 From the scientific necessity to adequately power a study through research collaborations is also born an ethical imperative to do so. That is, the anticipated benefits and harms of a particular study are justified based on the researchers’ sound predictions about potential outcomes and contributions to knowledge. Either underestimating or overestimating translational possibilities can disturb the benefit–harm balance due largely to insufficient statistical power.5
Two important milestones, therefore, rest on this bench-to-bedside continuum for ‘omics’ research, and are essential for any clinical translation endeavour: research ethics and data-access reviews. The former ensures appropriate ongoing ethical oversight and participant protections, while the latter enables research collaboration by providing researchers with access to data. Debates surrounding traditional issues facing such reviews are ubiquitous in the literature, yet little attention has been paid to how these issues are exacerbated when studies span across multiple jurisdictions. This is particularly true for research typified in the ‘omics’ disciplines, where international collaboration is the norm rather than the exception.
Here, a distinction between multi-site and multi-jurisdictional research should be emphasised. While multi-site research implies that the project takes place across many individual sites, multi-jurisdictional research involves sites in different legal jurisdictions. Multi-jurisdictional research along with the ethics review processes required to …
Contributors MHZ and VR were responsible for data analysis with intellectual contribution from AJ and BMK. MHZ and VR drafted the article. All authors contributed to the conception and design of the paper, interpretation of data, critical revisions contributing to the intellectual content and approval of the final version of the manuscript.
Funding Maternal Infant Child and Youth Research Network (MICYRN); Canadian Partnership Against Cancer (CPAC).
Competing interests None declared.
Provenance and peer review Commissioned; externally peer reviewed.
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