Genome-wide significant association with seven novel multiple sclerosis risk loci

Christina M Lill; Felix Luessi; Antonio Alcina; Ekaterina A Sokolova; Nerea Ugidos; Belén de la Hera; Léna Guillot-Noël; Sunny Malhotra; Eva Reinthaler; Brit-Maren M Schjeide; Julia Y Mescheriakova; Andriy Mashychev; Inken Wohlers; Denis A Akkad; Orhan Aktas; Iraide Alloza; Alfredo Antigüedad; Rafa Arroyo; Ianire Astobiza; Paul Blaschke; Alexei N Boyko; Mathias Buttmann; Andrew Chan; Thomas Dörner; Joerg T Epplen; Olga O Favorova; Maria Fedetz; Oscar Fernández; Angel García-Martínez; Lisa-Ann Gerdes; Christiane Graetz; Hans-Peter Hartung; Sabine Hoffjan; Guillermo Izquierdo; Denis S Korobko; Antje Kroner; Christian Kubisch; Tania Kümpfel; Laura Leyva; Peter Lohse; Nadezhda A Malkova; Xavier Montalban; Ekaterina V Popova; Peter Rieckmann; Alexei S Rozhdestvenskii; Christiane Schmied; Inna V Smagina; Ekaterina Y Tsareva; Alexander Winkelmann; Uwe K Zettl; Harald Binder; Isabelle Cournu-Rebeix; Rogier Hintzen; Alexander Zimprich; Manuel Comabella; Bertrand Fontaine; Elena Urcelay; Koen Vandenbroeck; Maxim Filipenko; Fuencisla Matesanz; Frauke Zipp; Lars Bertram

doi:10.1136/jmedgenet-2015-103442

Article info

Immunogenetics

Original article

Genome-wide significant association with seven novel multiple sclerosis risk loci

Authors

Christina M Lill Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany PubMed articles Google scholar articles
Felix Luessi Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany PubMed articles Google scholar articles
Antonio Alcina Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain PubMed articles Google scholar articles
Ekaterina A Sokolova Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia PubMed articles Google scholar articles
Nerea Ugidos Neurogenomiks Laboratory, University of the Basque Country (UPV/EHU), Leioa, Spain Achucarro Basque Center for Neuroscience, Zamudio, Spain PubMed articles Google scholar articles
Belén de la Hera Immunology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Léna Guillot-Noël Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM F-75013, Paris, France PubMed articles Google scholar articles
Sunny Malhotra Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain PubMed articles Google scholar articles
Eva Reinthaler Department of Neurology, Medical University of Vienna, Vienna, Austria PubMed articles Google scholar articles
Brit-Maren M Schjeide Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany PubMed articles Google scholar articles
Julia Y Mescheriakova Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articles Google scholar articles
Andriy Mashychev Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany PubMed articles Google scholar articles
Inken Wohlers Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany PubMed articles Google scholar articles
Denis A Akkad Department of Human Genetics, Ruhr University, Bochum, Germany PubMed articles Google scholar articles
Orhan Aktas Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany PubMed articles Google scholar articles
Iraide Alloza Neurogenomiks Laboratory, University of the Basque Country (UPV/EHU), Leioa, Spain Achucarro Basque Center for Neuroscience, Zamudio, Spain IKERBASQUE, Basque Foundation for Science, Bilbao, Spain PubMed articles Google scholar articles
Alfredo Antigüedad Servicio de Neurología, Hospital Universitario de Basurto, Bilbao, Spain PubMed articles Google scholar articles
Rafa Arroyo Multiple Sclerosis Unit, Neurology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Ianire Astobiza Neurogenomiks Laboratory, University of the Basque Country (UPV/EHU), Leioa, Spain Achucarro Basque Center for Neuroscience, Zamudio, Spain PubMed articles Google scholar articles
Paul Blaschke Department of Neurology, University of Rostock, Rostock, Germany PubMed articles Google scholar articles
Alexei N Boyko Department of Neurology and Neurosurgery, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia PubMed articles Google scholar articles
Mathias Buttmann Department of Neurology, University of Würzburg, Würzburg, Germany PubMed articles Google scholar articles
Andrew Chan Department of Neurology, St. Josef-Hospital, Ruhr-University, Bochum, Germany PubMed articles Google scholar articles
Thomas Dörner Department of Medicine, Rheumatology, and Clinical Immunology & DRFZ, Charité University Medicine, Berlin, Germany PubMed articles Google scholar articles
Joerg T Epplen Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands Faculty of Health, University Witten/Herdecke, Witten, Germany PubMed articles Google scholar articles
Olga O Favorova Department of Molecular Biology and Medical Biotechnology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia PubMed articles Google scholar articles
Maria Fedetz Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain PubMed articles Google scholar articles
Oscar Fernández Unidad de Gestión Clínica de Neurociencias, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain PubMed articles Google scholar articles
Angel García-Martínez Immunology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Lisa-Ann Gerdes Institute of Clinical Neuroimmunology, Campus Grosshadern, Ludwig Maximilian University, Munich, Germany PubMed articles Google scholar articles
Christiane Graetz Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany PubMed articles Google scholar articles
Hans-Peter Hartung Department of Neurology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany PubMed articles Google scholar articles
Sabine Hoffjan Department of Human Genetics, Ruhr University, Bochum, Germany PubMed articles Google scholar articles
Guillermo Izquierdo Unidad de Esclerosis Múltiple, Hospital Universitario Virgen Macarena, Sevilla, Spain PubMed articles Google scholar articles
Denis S Korobko Multiple Sclerosis Center, Novosibirsk Regional State Clinical Hospital, Novosibirsk, Russia PubMed articles Google scholar articles
Antje Kroner Department of Neurology, University of Würzburg, Würzburg, Germany Medical College of Wisconsin, Milwaukee, Wisconsin, USA PubMed articles Google scholar articles
Christian Kubisch Institute of Human Genetics, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany PubMed articles Google scholar articles
Tania Kümpfel Institute of Clinical Neuroimmunology, Campus Grosshadern, Ludwig Maximilian University, Munich, Germany PubMed articles Google scholar articles
Laura Leyva Unidad de Gestión Clínica de Neurociencias, Instituto de Biomedicina de Málaga (IBIMA), Hospital Regional Universitario de Málaga, Málaga, Spain PubMed articles Google scholar articles
Peter Lohse Department of Clinical Chemistry, Ludwig Maximilian University, Munich, Germany CeGaT GmbH, Tuebingen, Germany PubMed articles Google scholar articles
Nadezhda A Malkova Multiple Sclerosis Center, Novosibirsk Regional State Clinical Hospital, Novosibirsk, Russia Department of Clinical Neurology and Algology, Novosibirsk State Medical University, Novosibirsk, Russia PubMed articles Google scholar articles
Xavier Montalban Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain PubMed articles Google scholar articles
Ekaterina V Popova Department of Neurology and Neurosurgery, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia PubMed articles Google scholar articles
Peter Rieckmann Department of Neurology, University of Würzburg, Würzburg, Germany Department of Neurology, Sozialstiftung Bamberg Hospital, Bamberg, Germany PubMed articles Google scholar articles
Alexei S Rozhdestvenskii Department of Neurology of Postgraduate Education, Omsk State Medical Academy, Omsk, Russia PubMed articles Google scholar articles
Christiane Schmied Department of Neurology, Medical University of Vienna, Vienna, Austria PubMed articles Google scholar articles
Inna V Smagina Territorial Clinical Hospital, Barnaul, Russia Department of Nervous Diseases, Altai State Medical University, Barnaul, Russia PubMed articles Google scholar articles
Ekaterina Y Tsareva Department of Molecular Biology and Medical Biotechnology, Pirogov Russian National Research Medical University (RNRMU), Moscow, Russia PubMed articles Google scholar articles
Alexander Winkelmann Department of Neurology, University of Rostock, Rostock, Germany PubMed articles Google scholar articles
Uwe K Zettl Department of Neurology, University of Rostock, Rostock, Germany PubMed articles Google scholar articles
Harald Binder Institute for Medical Biostatistics, Epidemiology and Informatics (IMBEI), University Medical Center Mainz, Mainz, Germany PubMed articles Google scholar articles
Isabelle Cournu-Rebeix Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM F-75013, Paris, France PubMed articles Google scholar articles
Rogier Hintzen Department of Neurology, MS Centre ErasMS, Erasmus Medical Centre, Rotterdam, The Netherlands PubMed articles Google scholar articles
Alexander Zimprich Department of Neurology, Medical University of Vienna, Vienna, Austria PubMed articles Google scholar articles
Manuel Comabella Department of Neurology-Neuroimmunology, Centre d'Esclerosi Múltiple de Catalunya, Cemcat, Hospital Universitari Vall d´Hebron (HUVH), Barcelona, Spain PubMed articles Google scholar articles
Bertrand Fontaine Sorbonne Universités, UPMC Univ Paris 06 UMR S 1127, Inserm U 1127, CNRS UMR 7225, ICM F-75013, Paris, France AP-HP, Départment of des Maladies du Système Nerveux, Pitié-Salpêtrère Hospital, Paris, France PubMed articles Google scholar articles
Elena Urcelay Immunology Department, Hospital Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain PubMed articles Google scholar articles
Koen Vandenbroeck Neurogenomiks Laboratory, University of the Basque Country (UPV/EHU), Leioa, Spain Achucarro Basque Center for Neuroscience, Zamudio, Spain IKERBASQUE, Basque Foundation for Science, Bilbao, Spain PubMed articles Google scholar articles
Maxim Filipenko Laboratory of Pharmacogenomics, Institute of Chemical Biology and Fundamental Medicine, Siberian Division, Russian Academy of Sciences, Novosibirsk, Russia Novosibirsk State University, Novosibirsk, Russia PubMed articles Google scholar articles
Fuencisla Matesanz Department of Cell Biology and Immunology, Instituto de Parasitología y Biomedicina López Neyra (IPBLN), CSIC, Granada, Spain PubMed articles Google scholar articles
Frauke Zipp Department of Neurology, Focus Program Translational Neuroscience, University Medical Center of the Johannes Gutenberg-University Mainz, Mainz, Germany PubMed articles Google scholar articles
Lars Bertram Platform for Genome Analytics, Institutes of Neurogenetics & Integrative and Experimental Genomics, University of Lübeck, Lübeck, Germany Department of Vertebrate Genomics, Max Planck Institute for Molecular Genetics, Berlin, Germany Department of Medicine, School of Public Health, Imperial College London, London, UK PubMed articles Google scholar articles

Correspondence to Dr Christina M Lill, Institute of Neurogenetics, University of Lübeck, Maria-Goeppert-Str. 1, Lübeck 23562, Germany; christina.lill{at}uni-luebeck.de

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Citation

Lill CM, Luessi F, Alcina A, et al

Genome-wide significant association with seven novel multiple sclerosis risk loci

Journal of Medical Genetics 2015;52:848-855.

Publication history

Received August 6, 2015
Revised September 3, 2015
Accepted September 17, 2015
First published October 16, 2015.

Online issue publication

April 27, 2016

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