Clinical and molecular predictors of mortality in neurofibromatosis 2: a UK national analysis of 1192 patients

Adam Hexter; Adrian Jones; Harry Joe; Laura Heap; Miriam J Smith; Andrew J Wallace; Dorothy Halliday; Allyson Parry; Amy Taylor; Lucy Raymond; Adam Shaw; Shazia Afridi; Rupert Obholzer; Patrick Axon; Andrew T King; The English Specialist NF2 Research Group; Jan M Friedman; D Gareth R Evans

doi:10.1136/jmedgenet-2015-103290

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Genotype-phenotype correlations

Original article

Clinical and molecular predictors of mortality in neurofibromatosis 2: a UK national analysis of 1192 patients

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Adam Hexter Manchester Centre for Genomic Medicine, Central Manchester NHS Foundation Trust, St Mary's Hospital, Manchester, UK PubMed articles Google scholar articles
Adrian Jones Department of Statistics, University of British Columbia, Vancouver, Canada PubMed articles Google scholar articles
Harry Joe Department of Statistics, University of British Columbia, Vancouver, Canada PubMed articles Google scholar articles
Laura Heap Manchester Centre for Genomic Medicine, Central Manchester NHS Foundation Trust, St Mary's Hospital, Manchester, UK PubMed articles Google scholar articles
Miriam J Smith Manchester Centre for Genomic Medicine, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK PubMed articles Google scholar articles
Andrew J Wallace Manchester Centre for Genomic Medicine, Central Manchester NHS Foundation Trust, St Mary's Hospital, Manchester, UK PubMed articles Google scholar articles
Dorothy Halliday Medical Genetics, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Allyson Parry Neurology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK PubMed articles Google scholar articles
Amy Taylor Medical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK PubMed articles Google scholar articles
Lucy Raymond Medical Genetics, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK PubMed articles Google scholar articles
Adam Shaw Department of Medical Genetics, Guy's and St. Thomas’ Hospital, London, UK PubMed articles Google scholar articles
Shazia Afridi Department of Neurology, Guy's and St. Thomas’ Hospital, London, UK PubMed articles Google scholar articles
Rupert Obholzer Department of Ear, Nose and Throat, Guy's and St. Thomas’ Hospital, London, UK PubMed articles Google scholar articles
Patrick Axon Department of Otolaryngology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK PubMed articles Google scholar articles
Andrew T King Department of Neurosurgery, Salford Royal NHS Foundation Trust, St. Mary's Hospital, Manchester, UK PubMed articles Google scholar articles
The English Specialist NF2 Research Group
Google scholar articles
Jan M Friedman Department of Medical Genetics, University of British Columbia, Vancouver, Canada Child & Family Research Institute, Vancouver, Canada PubMed articles Google scholar articles
D Gareth R Evans Manchester Centre for Genomic Medicine, Central Manchester NHS Foundation Trust, St Mary's Hospital, Manchester, UK Manchester Centre for Genomic Medicine, Institute of Human Development, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK PubMed articles Google scholar articles

Correspondence to Professor J M Friedman, Medical Genetics Research Unit, Children's & Women's Hospital, Box 153, 4500 Oak Street, Vancouver, B.C. Canada V6H 3N1; jan.friedman{at}ubc.ca

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Citation

Hexter A, Jones A, Joe H, et al

Clinical and molecular predictors of mortality in neurofibromatosis 2: a UK national analysis of 1192 patients

Journal of Medical Genetics 2015;52:699-705.

Publication history

Received May 28, 2015
Revised June 23, 2015
Accepted July 22, 2015
First published August 14, 2015.

Online issue publication

September 22, 2015

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