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  • Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

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Genome-wide studies
Original article
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance

Authors

  • Yolande F M Ramos Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Sarah Metrustry Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articlesGoogle scholar articles
  • Nigel Arden NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK Arthritis Research UK, Sport, Exercise and Osteoarthritis Centre of Excellence, London, UK PubMed articlesGoogle scholar articles
  • Anne C Bay-Jensen Department of Rheumatology, Nordic Bioscience, Herlev, Denmark PubMed articlesGoogle scholar articles
  • Marian Beekman Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Anton J M de Craen Department of Gerontology and Geriatrics, LUMC, Leiden, The Netherlands The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • L Adrienne Cupples Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA The Framingham Heart Study, Framingham, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Tõnu Esko Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia Department of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA Broad Institute, Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Evangelos Evangelou Department of Hygiene & Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articlesGoogle scholar articles
  • David T Felson Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA PubMed articlesGoogle scholar articles
  • Deborah J Hart Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articlesGoogle scholar articles
  • John P A Ioannidis Department of Hygiene & Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece Department of Medicine, Stanford Prevention Research Center, Stanford, USA Department of Health Research and Policy, Stanford University School of Medicine, Stanford, USA Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, USA PubMed articlesGoogle scholar articles
  • Morten Karsdal Department of Rheumatology, Nordic Bioscience, Herlev, Denmark PubMed articlesGoogle scholar articles
  • Margreet Kloppenburg Department of Rheumatology & Clinical Epidemiology, LUMC, Leiden, The Netherlands PubMed articlesGoogle scholar articles
  • Floris Lafeber Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Andres Metspalu Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia PubMed articlesGoogle scholar articles
  • Kalliope Panoutsopoulou Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK PubMed articlesGoogle scholar articles
  • P Eline Slagboom Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Tim D Spector Department of Twin Research & Genetic Epidemiology, King's College London, London, UK PubMed articlesGoogle scholar articles
  • Erwin W E van Spil Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands PubMed articlesGoogle scholar articles
  • Andre G Uitterlinden The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Yanyan Zhu Global Analytical Science, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA PubMed articlesGoogle scholar articles
  • arcOGEN consortium
    Google scholar articles
  • TreatOA collaborators
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  • Ana M Valdes Academic Rheumatology, University of Nottingham, Nottingham, UK PubMed articlesGoogle scholar articles
  • Joyce B J van Meurs The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  • Ingrid Meulenbelt Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands PubMed articlesGoogle scholar articles
  1. Correspondence to Dr Yolande F M Ramos, Department of Molecular Epidemiology, Leiden University Medical Center, LUMC Postzone S-05-P, P.O. Box 9600, Leiden 2300 RC, The Netherlands; y.f.m.ramos{at}lumc.nl
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Citation

Ramos YFM, Metrustry S, Arden N, et al
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance
Journal of Medical Genetics 2014;51:596-604.

Publication history

  • Received April 14, 2014
  • Revised June 11, 2014
  • Accepted June 25, 2014
  • First published July 23, 2014.
Online issue publication 
August 12, 2014

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