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Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance
  1. Yolande F M Ramos1,2,
  2. Sarah Metrustry3,
  3. Nigel Arden4,5,
  4. Anne C Bay-Jensen6,
  5. Marian Beekman1,2,
  6. Anton J M de Craen7,2,
  7. L Adrienne Cupples8,9,
  8. Tõnu Esko10,11,12,
  9. Evangelos Evangelou13,3,
  10. David T Felson14,
  11. Deborah J Hart3,
  12. John P A Ioannidis13,15,16,17,
  13. Morten Karsdal6,
  14. Margreet Kloppenburg18,
  15. Floris Lafeber19,
  16. Andres Metspalu10,
  17. Kalliope Panoutsopoulou20,
  18. P Eline Slagboom1,2,
  19. Tim D Spector3,
  20. Erwin W E van Spil19,
  21. Andre G Uitterlinden2,21,
  22. Yanyan Zhu22,
  23. arcOGEN consortium,
  24. TreatOA collaborators,
  25. Ana M Valdes23,
  26. Joyce B J van Meurs2,21,
  27. Ingrid Meulenbelt1,2
  1. 1Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands
  2. 2The Netherlands Genomics Initiative-Sponsored Netherlands Consortium for Healthy Aging, Leiden and Rotterdam, The Netherlands
  3. 3Department of Twin Research & Genetic Epidemiology, King's College London, London, UK
  4. 4NIHR Musculoskeletal Biomedical Research Unit, University of Oxford, Oxford, UK
  5. 5Arthritis Research UK, Sport, Exercise and Osteoarthritis Centre of Excellence, London, UK
  6. 6Department of Rheumatology, Nordic Bioscience, Herlev, Denmark
  7. 7Department of Gerontology and Geriatrics, LUMC, Leiden, The Netherlands
  8. 8Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
  9. 9The Framingham Heart Study, Framingham, Massachusetts, USA
  10. 10Institute of Molecular and Cell Biology and Estonian Genome Center, University of Tartu, Tartu, Estonia
  11. 11Department of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA
  12. 12Broad Institute, Cambridge, Massachusetts, USA
  13. 13Department of Hygiene & Epidemiology, University of Ioannina School of Medicine, Ioannina, Greece
  14. 14Clinical Epidemiology Unit, Boston University School of Medicine, Boston, Massachusetts, USA
  15. 15Department of Medicine, Stanford Prevention Research Center, Stanford, USA
  16. 16Department of Health Research and Policy, Stanford University School of Medicine, Stanford, USA
  17. 17Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, USA
  18. 18Department of Rheumatology & Clinical Epidemiology, LUMC, Leiden, The Netherlands
  19. 19Department of Rheumatology & Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands
  20. 20Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
  21. 21Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands
  22. 22Global Analytical Science, Takeda Pharmaceuticals International Co., Cambridge, Massachusetts, USA
  23. 23Academic Rheumatology, University of Nottingham, Nottingham, UK
  1. Correspondence to Dr Yolande F M Ramos, Department of Molecular Epidemiology, Leiden University Medical Center, LUMC Postzone S-05-P, P.O. Box 9600, Leiden 2300 RC, The Netherlands; y.f.m.ramos{at}lumc.nl

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