Article Text

Download PDFPDF
Original article
Intake levels of dietary polyunsaturated fatty acids modify the association between the genetic variation in PCSK5 and HDL cholesterol
  1. Han Byul Jang1,
  2. Joo-Yeon Hwang2,
  3. Ji Eun Park1,
  4. Ji Hee Oh2,
  5. YounJhin Ahn1,2,
  6. Jae-Heon Kang3,
  7. Kyung-Hee Park4,
  8. Bok-Ghee Han2,
  9. Bong Jo Kim2,
  10. Sang Ick Park1,
  11. Hye-Ja Lee1
  1. 1Center for Biomedical Science, Korea National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, South Korea
  2. 2Center for Genome Science, Korea National Institute of Health, Cheongwon-gun, Chungcheongbuk-do, South Korea
  3. 3Department of Family Medicine, Obesity Research Institute, Seoul-Paik Hospital, Inje University, Seoul, South Korea
  4. 4Department of Family Medicine, Hallym University Sacred Heart Hospital, Hallym University, Anyang, Gyeonggi-do, South Korea
  1. Correspondence to Sang Ick Park and Hye-Ja Lee, Center for Biomedical Science, Korea National Institute of Health, Choengwon-gun, Chungcheongbuk-do 363-951, South Korea; parksi61{at} and hyejalee{at}


Background A low serum level of high-density lipoprotein cholesterol (HDL-C) is a risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 5 (PCSK5) modulates HDL-C metabolism through the inactivation of endothelial lipase activity.

Methods Therefore, we analysed the effects of PCSK5 on HDL-C and investigated the association between genetic variation in PCSK5 and dietary polyunsaturated fatty acids (PUFAs) intakes in Korean adults and children. This population-based study which was conducted in South Korea included 4205 adults (43% male) aged 40–69 years and 1548 children (48.6% boys) aged 8–13 years. Dietary intake was assessed using a semiquantitative food frequency questionnaire in adults and modified 3-day food records in children.

Results After adjustments for age and body mass index, we identified a significant association between SNP rs1029035 of the PCSK5 gene and HDL-C concentrations specifically for men in both populations (adults, p=0.004; children, p=0.003; meta, p=7×10−4). Additionally, the interaction between the PCSK5 rs1029035 genotype and dietary polyunsaturated fatty acids intake influenced serum HDL-C concentrations in men (adults, p=0.001; children, p=0.008). The deleterious effect of the C allele on serum HDL-C was present only when dietary PUFA intake was less than the dichotomised median level (adults, p=0.011; children, p=0.001). Serum HDL-C concentrations were decreased in men with the C allele genotype and low consumption of dietary PUFA including n-3 and n-6.

Conclusion According to these results, men carrying of the C allele were associated with low HDL-C concentrations and might exert beneficial effects on HDL-C concentrations following consumption of a high-PUFA diet.

  • Genetic epidemiology
  • Nutrition and Metabolism
  • Complex traits

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.