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Evaluating the performance of the breast cancer genetic risk models BOADICEA, IBIS, BRCAPRO and Claus for predicting BRCA1/2 mutation carrier probabilities: a study based on 7352 families from the German Hereditary Breast and Ovarian Cancer Consortium
  1. Christine Fischer1,
  2. Karoline Kuchenbäcker2,
  3. Christoph Engel3,
  4. Silke Zachariae3,
  5. Kerstin Rhiem4,
  6. Alfons Meindl5,
  7. Nils Rahner6,
  8. Nicola Dikow1,
  9. Hansjörg Plendl7,
  10. Irmgard Debatin8,
  11. Tiemo Grimm9,
  12. Dorothea Gadzicki10,
  13. Ricarda Flöttmann11,
  14. Judit Horvath12,
  15. Evelin Schröck13,
  16. Friedrich Stock14,
  17. Dieter Schäfer15,
  18. Ira Schwaab16,
  19. Christiana Kartsonaki2,17,
  20. Nasim Mavaddat2,
  21. Brigitte Schlegelberger10,
  22. Antonis C Antoniou2,
  23. Rita Schmutzler4,
  24. on behalf of the German Consortium for Hereditary Breast and Ovarian Cancer
  1. 1Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
  2. 2Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK
  3. 3Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany
  4. 4Department of Gynaecology and Obstetrics, Center for Familiar Breast and Ovarian Cancer, University Hospital of Cologne, Köln, Germany
  5. 5Department of Obstetrics and Gynecology, Division of Tumor Genetics, Klinikum rechts der Isar der Technischen Universität Muenchen, Munich, Germany
  6. 6Institute of Human Genetics, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany
  7. 7Institute of Human Genetics, University Hospital of Schleswig-Holstein, Campus Kiel, Christian-Albrechts-University of Kiel, Kiel, Germany
  8. 8Institute of Human Genetics, University of Ulm, Ulm, Germany
  9. 9Institute of Human Genetics, Biozentrum University of Würzburg, Würzburg, Germany
  10. 10Institute of Cell and Molecular Pathology, Medical School Hannover, Hannover, Germany
  11. 11Institute of Medical Genetics and Human Genetics, Charite’-Universitätsmedizin Berlin, Berlin, Germany
  12. 12Institute of Human Genetics, University of Münster, Münster, Germany
  13. 13Institute of Clinical Genetics, Medical School, Technical University of Dresden, Dresden, Germany
  14. 14Institute of Human Genetics, University of Leipzig, Leipzig, Germany
  15. 15Institute of Human Genetics, University of Frankfurt/Main, Frankfurt/Main, Germany
  16. 16Praxis für Humangenetik, Wiesbaden, Germany
  17. 17Department of Statistics, University of Oxford, Oxford, UK
  1. Correspondence to Dr Christine Fischer, Institute of Human Genetics, University of Heidelberg, Im Neuenheimer Feld 366, Heidelberg 69120, Germany; cfischer{at}uni-hd.de

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