Article Text

Download PDFPDF

Targeting branch sites of new exons?
  1. Igor Vorechovsky
  1. Correspondence to Dr Igor Vorechovsky, HDH, University of Southampton, MP808, Southampton SO16 6YD, UK; igvo{at}

Statistics from

Martinez et al1 reported an interesting case of Dubowitz-like syndrome associated with an acceptor splice site mutation, leading to the use of a cryptic splice donor site in an Alu sequence. Their explanation for the resulting aberrant transcripts was limited to a referral to Alu polyA tails and Alu-derived microRNAs.1 Upon mutation of acceptor sites, the spliceosome machinery tries to find suitable alternative 3′ splice sites nearby. If none is available, which …

View Full Text

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.