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Targeting branch sites of new exons?
  1. Igor Vorechovsky
  1. Correspondence to Dr Igor Vorechovsky, HDH, University of Southampton, MP808, Southampton SO16 6YD, UK; igvo{at}soton.ac.uk

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Martinez et al1 reported an interesting case of Dubowitz-like syndrome associated with an acceptor splice site mutation, leading to the use of a cryptic splice donor site in an Alu sequence. Their explanation for the resulting aberrant transcripts was limited to a referral to Alu polyA tails and Alu-derived microRNAs.1 Upon mutation of acceptor sites, the spliceosome machinery tries to find suitable alternative 3′ splice sites nearby. If none is available, which …

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