Background The authors previously showed that the C→T polymorphism (rs6929846) of butyrophilin, subfamily 2, member A1 gene (BTN2A1) was significantly associated with myocardial infarction in Japanese individuals. Given that metabolic syndrome (MetS) is an important risk factor for myocardial infarction, the association of the rs6929846 of BTN2A1 with myocardial infarction might be attributable, at least in part, to its effect on susceptibility to MetS.
Aim The aim of the present study was to examine the relation of the rs6929846 of BTN2A1 to MetS in East Asian populations.
Methods The study population comprised 5210 Japanese or Korean individuals (3982 individuals with MetS, 1228 controls) from three independent subject panels. Japanese subject panels A and B comprised 1322 individuals with MetS and 654 controls, and 1909 individuals with MetS and 170 controls, respectively, whereas the Korean population samples comprised 751 individuals with MetS and 404 controls.
Results Comparison of genotype distributions using the χ2 test revealed that the genotype distributions and allele frequencies of rs6929846 were significantly (p<0.05) associated with MetS in Japanese subject panels A (T allele frequency: MetS, 0.091; controls, 0.054; p=6.1×10−5) and B (T allele frequency: MetS, 0.091; controls, 0.039; p=0013) but not in the Korean population samples (T allele frequency: MetS, 0.102; controls, 0.125; p=0.0997). Multivariable logistic regression analysis with adjustment for covariates revealed that the rs6929846 of BTN2A1 was significantly (p<0.017) associated with MetS in Japanese subject panel A (p=0.0055, OR 1.97) and in all individuals (p=0.0038, OR 1.38), with the T allele representing a risk factor for this condition.
Conclusion BTN2A1 may be a susceptible gene for MetS in Japanese individuals.
- Metabolic syndrome
- cardiovascular medicine, hypertension
- lipid disorders
- metabolic disorders
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Funding This work was supported by Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan (Nos. 18209023, 18018021 and 19659149 to YY) and by a research grant from Mie Medical Valley Project (to YY).
Competing interests None.
Ethics approval This study was conducted with the approval of the institutional review boards. For the Japanese samples, the study protocol complied with the Declaration of Helsinki and was approved by the committees on the ethics of human research of the Mie University Graduate School of Medicine, the Hirosaki University Graduate School of Medicine, the Gifu International Institute of Biotechnology, the Tokyo Metropolitan Institute of Gerontology and participating hospitals. Written informed consent was obtained from each subject. For the Korean samples, the study protocol complied with the Guidelines for Genome/Genetic Research issued by the Korean government and was approved by the institutional review board of Yonsei University. Written informed consent was obtained from each participant.
Provenance and peer review Not commissioned; externally peer reviewed.